Search our portfolio

Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

61 results

RespiraTox: In silico model for predicting human respiratory irritation

Contractor: Dr Sylvia Escher, Fraunhofer ITEM

CRACK IT Challenge

Validating the cross-species comparative in silico platform (CRISP)

Contractor: Dr Will Krawszik, Moleculomics

CRACK IT Solution

Retinal 3D: 3D hiPSC derived laminated retinal model as a tool for toxicology studies

Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd

CRACK IT Challenge

Osteo-chip: Microfluidic Automated Platform for Osteoarthritis Drug Screening (MA-PODS)

Contractor: Professor Anne Dickinson, Alcyomics Ltd

CRACK IT Challenge

X-ray graphic of legs, the right leg has joint pain

Non-invasive in vivo tissue imaging with functional optical coherence tomography (OCT)

Contractor: Professor Zhihong Huang, University of Dundee

CRACK IT Solution

Four 3D structual images of tissue of tissue imaging with functional optical coherence tomography

Maximise: Integrated web platform for agro-chemical formulation toxicity classification and data sharing

Contractor: Professor Jonathan Timmis, SimOmics Ltd

CRACK IT Challenge

Neuroinflammation and nociception in a dish

Contractor: Professor Adalberto Merighi, University of Turin

CRACK IT Solution

Neuroinflammation and nociception in a dish

EASE: Design, Fabrication and Testing of a Mouse Embryo Culture Chip

Contractor: Dr Virginia Pensabene, University of Leeds

CRACK IT Challenge

Using chicken eggs to advance the 3Rs in cancer drug discovery

Contractor: Dr Jean Viallet

CRACK IT Solution

Injecting a chicken egg under a spotlight

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Demuris)

Contractor: Dr Olivia Champion, Biosystems Technology

CRACK IT Solution

Galleria mellonella larvaes in a green tub

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Envigo)

Contractor: Dr Olivia Champion, Biosystems Technology

CRACK IT Solution

Metaboderm: 3D hiPSC derived skin model and in-silico skin modelling of metabolism

Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd

CRACK IT Challenge

InMutaGene: A human IPS cell model for gene therapy vector safety evaluation

Contractor: Dr Manfred Schmidt, GeneWerk GmbH

CRACK IT Challenge

Comprehensive target screening by label-free cell microarray profiling to reduce animal efficacy and toxicology studies in drug discovery

Contractor: Dr James Sidaway, Phenotox Ltd

CRACK IT Solution

Four stages of target screening by label-free cell microarray profiling

Portable bioluminescence test for botulinum neurotoxin

Contractor: Dr Gregory Stevens, University of Freiburg

CRACK IT Solution

A graphic showing a bead, linker, cleavage site and bont

Affimers: animal free alternatives to antibodies

Contractor: Philip Cotrel, Avacta Life Sciences

CRACK IT Solution

Neuratect: microfluidic microtiter plates for in vitro neurotoxicity screening

Contractor: Dr Jos Joore, MIMETAS, BV

CRACK IT Challenge

Rodent Big Brother

Contractor: Professor Douglas Armstrong

CRACK IT Solution

ZeGlobalTox: multi-organ toxicity testing in zebrafish

Contractor: Dr Davide D'Amico, ZeClinics SL

CRACK IT Solution

Inhalation Translation: Differentiating alveolar macrophage responses to inhaled medicines

Contractor: Dr Ben Forbes, Kings College London

CRACK IT Challenge