Portable bioluminescence test for botulinum neurotoxin Contractor: Dr Gregory Stevens, CRACK IT Solution
Neuratect: microfluidic microtiter plates for in vitro neurotoxicity screening Contractor: Dr Jos Joore, MIMETAS, BV, CRACK IT Challenge
Inhalation Translation: Differentiating alveolar macrophage responses to inhaled medicines Contractor: Dr Ben Forbes, Kings College London, CRACK IT Challenge
A novel product for reducing animal numbers in the production of transgenic mice Contractor: Ostara Biomedical Ltd, CRACK IT Solution
QSARs Mix: Development of high accuracy QSARs for mixtures to bridge the data gaps in skin and eye irritation Contractor: Dr Paul Thomas, KREATiS, CRACK IT Challenge
DRGNET: Developing an ethical, sustainable, human sensory neuron culture model for use in therapeutic pain research Contractor: Professor Andrew Hart, NHS Greater Glasgow & Clyde, CRACK IT Challenge
NephroTube: toxicity screening with a human renal cell line in a perfused titerplate Contractor: Northwestern Switzerland, CRACK IT Challenge
VIDR: A multiscale model to minimise animal usage in Leishmaniasis drug development Contractor: Professor Paul Kaye, University of York, CRACK IT Challenge
UnTangle: A microfluidics based drug-screening platform for human tau mutation neurons Contractor: Dr Selina Wray, University College London, CRACK IT Challenge
InPulse: Engineered 2D & 3D hiPSC-CM platforms to detect cardiovascular safety liabilities Contractor: Professor Chris Denning, University of Nottingham, CRACK IT Challenge
Using human pluripotent stem cell-derived cardiomyocytes to test drug cardiac toxicity Contractor: Dr Tamer Mohammed, CRACK IT Solution
PREDART: An integrative Dictyostelium, C. elegans and zebrafish approach to assess DART Contractor: Professor Raymond Peters, Institute for Risk Assessment Sciences/ Toxicology, U…, CRACK IT Challenge
An early screen for emetic liability of NCEs using the amoeba Dictyostelium Contractor: Professor Robin Williams, CRACK IT Solution
State of the art in vitro models which accurately predict human liver toxicity Contractor: Dr Dave Hay, CRACK IT Solution