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60 results

Validating the cross-species comparative in silico platform (CRISP)

Contractor: Dr Will Krawszik, Moleculomics

CRACK IT Solution

Retinal 3D: 3D hiPSC derived laminated retinal model as a tool for toxicology studies

Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd

CRACK IT Challenge

Osteo-chip: Microfluidic Automated Platform for Osteoarthritis Drug Screening (MA-PODS)

Contractor: Professor Anne Dickinson, Alcyomics Ltd

CRACK IT Challenge

X-ray graphic of legs, the right leg has joint pain

Non-invasive in vivo tissue imaging with functional optical coherence tomography (OCT)

Contractor: Professor Zhihong Huang, University of Dundee

CRACK IT Solution

Four 3D structual images of tissue of tissue imaging with functional optical coherence tomography

Maximise: Integrated web platform for agro-chemical formulation toxicity classification and data sharing

Contractor: Professor Jonathan Timmis, SimOmics Ltd

CRACK IT Challenge

Neuroinflammation and nociception in a dish

Contractor: Professor Adalberto Merighi, University of Turin

CRACK IT Solution

Neuroinflammation and nociception in a dish

EASE: Design, Fabrication and Testing of a Mouse Embryo Culture Chip

Contractor: Dr Virginia Pensabene, University of Leeds

CRACK IT Challenge

Using chicken eggs to advance the 3Rs in cancer drug discovery

Contractor: Dr Jean Viallet

CRACK IT Solution

Injecting a chicken egg under a spotlight

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Demuris)

Contractor: Dr Olivia Champion, Biosystems Technology

CRACK IT Solution

Galleria mellonella larvaes in a green tub

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Envigo)

Contractor: Dr Olivia Champion, Biosystems Technology

CRACK IT Solution

Metaboderm: 3D hiPSC derived skin model and in-silico skin modelling of metabolism

Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd

CRACK IT Challenge

InMutaGene: A human IPS cell model for gene therapy vector safety evaluation

Contractor: Dr Manfred Schmidt, GeneWerk GmbH

CRACK IT Challenge

Comprehensive target screening by label-free cell microarray profiling to reduce animal efficacy and toxicology studies in drug discovery

Contractor: Dr James Sidaway, Phenotox Ltd

CRACK IT Solution

Four stages of target screening by label-free cell microarray profiling

Portable bioluminescence test for botulinum neurotoxin

Contractor: Dr Gregory Stevens, University of Freiburg

CRACK IT Solution

A graphic showing a bead, linker, cleavage site and bont

Affimers: animal free alternatives to antibodies

Contractor: Philip Cotrel, Avacta Life Sciences

CRACK IT Solution

Neuratect: microfluidic microtiter plates for in vitro neurotoxicity screening

Contractor: Dr Jos Joore, MIMETAS, BV

CRACK IT Challenge

Rodent Big Brother

Contractor: Professor Douglas Armstrong

CRACK IT Solution

ZeGlobalTox: multi-organ toxicity testing in zebrafish

Contractor: Dr Davide D'Amico, ZeClinics SL

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Inhalation Translation: Differentiating alveolar macrophage responses to inhaled medicines

Contractor: Dr Ben Forbes, Kings College London

CRACK IT Challenge

A novel product for reducing animal numbers in the production of transgenic mice

Contractor: Dr Nadia Gopichandran, Ostara Biomedical Ltd

CRACK IT Solution

An Ostara device measured at 8 centimeters