Stem cell-derived cardiomyocytes for detection of cardiotoxicity in cancer therapeutics Principal Investigator: Professor Sian Harding, Imperial College London Project grant
A 3D tissue model of breast morphogenesis for replacing animals in testing for endocrine disrupting substances Principal Investigator: Professor Charles Vyvyan Howard, University of Ulster Project grant
The validation of defined genotoxic thresholds, leading to better in vitro risk assessments of carcinogenic potential Principal Investigator: Professor Gareth Jenkins, Swansea University PhD Studentship
An in vitro model system to assay kidney-pathogen interactions determining outcome of Candida albicans infection Principal Investigator: Dr Donna MacCallum, University of Aberdeen PhD Studentship
Replacement of animals in cancer drug development by using 3D in vitro functional assays for increased predictive power Principal Investigator: Dr Louis Chesler, Institute of Cancer Research Project grant
Transgenic ES Cell Differentiation Systems to replace Transgenic Mouse Analysis of Tissue Specific Regulatory Elements Principal Investigator: Dr Berthold Gottgens, University of Cambridge Project grant
Reducing and replacing mouse use to model the human platelet response in vivo Principal Investigator: Dr Michael Emerson, Imperial College London Project grant
A compartmentalised chamber for the in vitro study and manipulation of axon degeneration Principal Investigator: Professor Victor Perry , University of Southampton Project grant
Drosophila as a model for Alzheimer's disease Principal Investigator: Dr Kevin Moffat, University of Warwick Project grant
Replacing, refining and reducing animal usage in epilepsy research using a non-sentient model Principal Investigator: Professor Robin Williams, Royal Holloway University of London Project grant
Engineering fully functional, integrated skeletal muscle Principal Investigator: Professor Mark Lewis, Loughborough University Project grant
Development and validation of in vitro methods for assaying cancer stem cell responses to therapeutic challenge Principal Investigator: Professor Ian MacKenzie, Queen Mary University of London Project grant
The snail assay as an alternative to the rodent Hershberger assay for detecting androgens and anti-androgens Principal Investigator: Dr Susan Jobling, Brunel University Project grant
The human tumour micro-environment modelled in in vitro biomatrices and applied to cancer drug discovery Principal Investigator: Dr Anna Grabowska, University of Nottingham Project grant
iPS cells from ALS patients: Towards replacing animal models for ALS Principal Investigator: Dr Vasanta Subramanian, University of Bath Project grant
Refinement of animal studies on emesis by defining human biomarkers of nausea Principal Investigator: Professor Qasim Aziz, Queen Mary University of London Project grant
Replacement in vitro assays for the quantification of clostridial vaccine antigens Principal Investigator: Dr Keith Redhead, Project grant
Establishment and validation of a stable, cell-based diabetic wound bioassay Principal Investigator: Professor Phil Stephens, Cardiff University Project grant
Carotid artery endothelial growth: a novel in vitro assay Principal Investigator: Dr Atticus Hainsworth, St George's University of London Project grant
Development and validation of mechanisms-based in vitro transformation assays for carcinogen screening Principal Investigator: Professor Robert Newbold, Brunel University Project grant