FIGCS: An in vitro model to replace ecotoxicity testing of fish to pharmaceuticals Principal Investigator: Professor Christer Hogstrand, King's College London Project grant
A chronic model of epilepsy in organotypic brain slice cultures of the rat entorhinal cortex Principal Investigator: Professor Roland Jones, University of Bath Project grant
Reducing mouse number in complex genetic experiments Principal Investigator: Dr Pieter Hohenstein, University of Edinburgh Project grant
A tissue engineered construct to monitor mucosal immunity in asthma Principal Investigator: Professor Donna Davies, University of Southampton Strategic grant
Zebrafish behavioural assays to identify genetic mechanisms underlying drug seeking and addiction Principal Investigator: Dr Caroline Brennan, Queen Mary University of London Project grant
Development of cell based assays as replacement assays for Botulinum toxins and antitoxins Principal Investigator: Dr Dorothea Sesardic, National Institute for Biological Standards and Control Project grant
Using the Drosophila fly intestine to investigate Wnt targets in vivo Principal Investigator: Dr Owen Sansom, University of Glasgow Project grant
Derivation of conditionally immortalised mouse DRG cell lines Principal Investigator: Dr Mohammed Nassar, University of Sheffield Project grant
Development of in vitro assays to determine vaccine efficacy in fish Principal Investigator: Professor Christopher Secombes, University of Aberdeen Project grant
Stem cell-derived cardiomyocytes for detection of cardiotoxicity in cancer therapeutics Principal Investigator: Professor Sian Harding, Imperial College London Project grant
A 3D tissue model of breast morphogenesis for replacing animals in testing for endocrine disrupting substances Principal Investigator: Professor Charles Vyvyan Howard, University of Ulster Project grant
Applying the 3Rs to liver fibrosis research Principal Investigator: Professor Matthew Wright, Newcastle University PhD Studentship
The validation of defined genotoxic thresholds, leading to better in vitro risk assessments of carcinogenic potential Principal Investigator: Professor Gareth Jenkins, Swansea University PhD Studentship
Taming anxiety and variation in laboratory mice Principal Investigator: Professor Jane Hurst, University of Liverpool PhD Studentship
Refinement of rearing practices in marmosets Principal Investigator: Professor Hannah Buchanan-Smith, University of Stirling PhD Studentship
An in vitro model system to assay kidney-pathogen interactions determining outcome of Candida albicans infection Principal Investigator: Dr Donna MacCallum, University of Aberdeen PhD Studentship
2Rs (refining and reducing) of animal models of multiple sclerosis Principal Investigator: Professor David Baker, Queen Mary University of London Project grant
Replacement of animals in cancer drug development by using 3D in vitro functional assays for increased predictive power Principal Investigator: Dr Louis Chesler, Institute of Cancer Research Project grant
Assessing the humaneness of gas euthanasia techniques for laboratory rodents Principal Investigator: Dr Huw Golledge, Newcastle University Strategic grant
Transgenic ES Cell Differentiation Systems to replace Transgenic Mouse Analysis of Tissue Specific Regulatory Elements Principal Investigator: Dr Berthold Gottgens, University of Cambridge Project grant