Recreating thrombosis models using tissue-engineered arterial constructs: A novel method to reduce and replace mice used in platelet research Principal Investigator: Dr Alan Harper, Keele University PhD Studentship
Development of E-Sense: a flexible in vitro platform to determine cardiovascular risk Principal Investigator: Dr Stephen White, Manchester Metropolitan University PhD Studentship
Investigation of key inflammatory cells & mediators in zebrafish larval tailfin & heart repair/regeneration following resolution of inflammation Principal Investigator: Professor Adriano Rossi, University of Edinburgh PhD Studentship
Reducing animal use in thrombosis research with an ex vivo injury model Principal Investigator: Dr Matthew Harper, University of Cambridge PhD Studentship
In silico human-based methodologies for evaluation of drug cardiac safety and efficacy Principal Investigator: Professor Blanca Rodriguez, University of Oxford Infrastructure grant
Development and characterisation of a human ex vivo model of aneurysm Principal Investigator: Dr Jason Johnson, University of Bristol PhD Studentship
ZeGlobalTox: multi-organ toxicity testing in zebrafish Contractor: Dr Davide D'Amico, ZeClinics SL CRACK IT Solution
Real-time monitoring techniques and simplistic platelet assays to reduce and refine animal use in cardiovascular and respiratory biomedical research Principal Investigator: Dr Michael Emerson, Imperial College London Project grant
InPulse: Engineered 2D & 3D hiPSC-CM platforms to detect cardiovascular safety liabilities Contractor: Professor Chris Denning, University of Nottingham CRACK IT Challenge
Using human pluripotent stem cell-derived cardiomyocytes to test drug cardiac toxicity Contractor: Dr Tamer Mohammed, University of Manchester CRACK IT Solution
Refining an established model of hypertension in the mouse Principal Investigator: Professor Susan Brain, King's College London PhD Studentship
SyRF: the CAMARADES/NC3Rs in vivo systematic review and meta-analysis facility Principal Investigator: Professor Malcolm Macleod, University of Edinburgh Infrastructure grant
Live imaging of mucosal and vascular inflammation in zebrafish in response to a high cholesterol diet Principal Investigator: Professor Margaret Dallman, Imperial College London PhD Studentship
Structural identifiability and indistinguishability analysis as tools for quantitative and systems pharmacology to support the 3Rs Principal Investigator: Dr Michael Chappell, University of Warwick Strategic grant
Feasibility of replacing invasive heart pressure measurements with non-invasive MR Elastography to reduce rodent numbers in pre-clinical research Principal Investigator: Dr Jurgen Schneider, University of Oxford Pilot study grant
Reducing and replacing mouse use to model the human platelet response in vivo Principal Investigator: Dr Michael Emerson, Imperial College London Project grant
Carotid artery endothelial growth: a novel in vitro assay Principal Investigator: Dr Atticus Hainsworth, St George's University of London Project grant
Refinement of a mouse model of pulmonary embolism Principal Investigator: Dr Michael Emerson, Imperial College London Project grant
Embryonic stem cell-derived cardiomyocytes as a model system for cardiac investigations Principal Investigator: Professor Sian Harding, Imperial College London Project grant