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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

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Topic

Model

Impact stories

61 results

A 3Rs approach to assess drug toxicity on the mammalian embryo during early pregnancy in vitro

Principal Investigator: Dr David Turner, University of Liverpool

PhD Studentship

Validating CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes as tools to assist with toxicity profiling, adverse drug reaction notices and black box warnings

Principal Investigator: Professor Chris Denning, University of Nottingham

Technologies to tools grant

Translating microvascularised chips of a nephrotoxicity model

Principal Investigator: Dr Julien Gautrot, Queen Mary University of London

Technologies to tools grant

Developing an in vitro repeat-dose test as a 3Rs approach to detect non-genotoxic carcinogens

Principal Investigator: Professor Gareth Jenkins, Swansea University

PhD Studentship

Moving the Adverse Outcome Pathways Framework towards Practical Utility by Integrating Compound Profiling Data and Using Deep Learning

Principal Investigator: Dr Andreas Bender, University of Cambridge

PhD Studentship

Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel

Principal Investigator: Dr Luigi Margiotta-Casaluci, Brunel University

Strategic grant

Developing alternative models to evaluate the impact of nanomaterials on neutrophils during the stimulation and resolution of inflammation

Principal Investigator: Dr Helinor Johnston, Heriot-Watt University

Project grant

In silico human-based methodologies for evaluation of drug cardiac safety and efficacy

Principal Investigator: Professor Blanca Rodriguez, University of Oxford

Infrastructure grant

Professor Blanca Rodriguez standing by a handrail

Novel biomarker platform for a 3Rs approach to assessment of developmental and reproductive toxicity

Principal Investigator: Dr Catherine Pears, University of Oxford

Project grant

Imprecision and importance: Probabilistic graphical models in toxicology

Principal Investigator: Dr Jonathan Pitchford, University of York

Strategic grant

Uncertainty and confidence in applying mathematical models and in vitro data in toxicological safety assessments

Principal Investigator: Dr John Gosling, University of Leeds

Strategic grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Structural identifiability and indistinguishability analysis as tools for quantitative and systems pharmacology to support the 3Rs

Principal Investigator: Dr Michael Chappell, University of Warwick

Strategic grant

An orange Eppendorf rack partly full of PCR tubes.

Human pluripotent stem cell cardiomyocytes and hepatocytes with engineered genotypes for drug safety evaluation

Principal Investigator: Professor Chris Denning, University of Nottingham

Project grant

Prediction of human cardiotoxic QT prolongation using in vitro multiple ion channel data and mathematical models of cardiac myocytes

Principal Investigator: Dr Gary Mirams, University of Oxford

Strategic grant

Combinatorial mathematical modelling & novel toxicological profiling of drug-induced hepatotoxicity

Principal Investigator: Dr John Ward, Loughborough University

PhD Studentship

The arm of a researcher pipetting cell culture media into multi-well plates

Refining, reducing and replacing in vivo WHO-standard preclinical assays of snake venom pathology and antivenom efficacy

Principal Investigator: Dr Robert Harrison, Liverpool School of Tropical Medicine

PhD Studentship

Developing an integrated "in vitro carcinogenicity predictive tool" utilising in vitro cell signalling and cell behaviour assessment coupled with in vitro genotoxicity data

Principal Investigator: Professor Gareth Jenkins, Swansea University

Strategic grant

Development of human epithelial cell transformation models for carcinogen screening, employing defined phenotypic endpoints mechanistically representative of rate-limiting events in human carcinogenesis

Principal Investigator: Professor Robert Newbold, Brunel University

Strategic grant

Pilot study investigating the use human stem cell derived neurons in toxicity testing

Principal Investigator: Dr Eric Hill, Aston University

Pilot study grant

FIGCS: An in vitro model to replace ecotoxicity testing of fish to pharmaceuticals

Principal Investigator: Professor Christer Hogstrand, King's College London

Project grant