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Activity type

Topic

Model

Impact stories

53 results

Novel biomarker platform for a 3Rs approach to assessment of developmental and reproductive toxicity

Principal Investigator: Dr Catherine Pears, University of Oxford

Project grant

Imprecision and importance: Probabilistic graphical models in toxicology

Principal Investigator: Dr Jonathan Pitchford, University of York

Strategic grant

Uncertainty and confidence in applying mathematical models and in vitro data in toxicological safety assessments

Principal Investigator: Dr John Gosling, University of Leeds

Strategic grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Structural identifiability and indistinguishability analysis as tools for quantitative and systems pharmacology to support the 3Rs

Principal Investigator: Dr Michael Chappell, University of Warwick

Strategic grant

An orange Eppendorf rack partly full of PCR tubes.

Human pluripotent stem cell cardiomyocytes and hepatocytes with engineered genotypes for drug safety evaluation

Principal Investigator: Professor Chris Denning, University of Nottingham

Project grant

Prediction of human cardiotoxic QT prolongation using in vitro multiple ion channel data and mathematical models of cardiac myocytes

Principal Investigator: Dr Gary Mirams, University of Oxford

Strategic grant

Combinatorial mathematical modelling & novel toxicological profiling of drug-induced hepatotoxicity

Principal Investigator: Dr John Ward, Loughborough University

PhD Studentship

Refining, reducing and replacing in vivo WHO-standard preclinical assays of snake venom pathology and antivenom efficacy

Principal Investigator: Dr Robert Harrison, Liverpool School of Tropical Medicine

PhD Studentship

Developing an integrated "in vitro carcinogenicity predictive tool" utilising in vitro cell signalling and cell behaviour assessment coupled with in vitro genotoxicity data

Principal Investigator: Professor Gareth Jenkins, Swansea University

Strategic grant

Development of human epithelial cell transformation models for carcinogen screening, employing defined phenotypic endpoints mechanistically representative of rate-limiting events in human carcinogenesis

Principal Investigator: Professor Robert Newbold, Brunel University

Strategic grant

Pilot study investigating the use human stem cell derived neurons in toxicity testing

Principal Investigator: Dr Eric Hill, Aston University

Pilot study grant

FIGCS: An in vitro model to replace ecotoxicity testing of fish to pharmaceuticals

Principal Investigator: Professor Christer Hogstrand, King's College London

Project grant

Development of cell based assays as replacement assays for Botulinum toxins and antitoxins

Principal Investigator: Dr Dorothea Sesardic, National Institute for Biological Standards and Control

Project grant

a photo showing a glass slide being held by a scientist, near to a microscope

Stem cell-derived cardiomyocytes for detection of cardiotoxicity in cancer therapeutics

Principal Investigator: Professor Sian Harding, Imperial College London

Project grant

A 3D tissue model of breast morphogenesis for replacing animals in testing for endocrine disrupting substances

Principal Investigator: Professor Charles Vyvyan Howard, University of Ulster

Project grant

A collection of test tubes containing coloured liquid

The validation of defined genotoxic thresholds, leading to better in vitro risk assessments of carcinogenic potential

Principal Investigator: Professor Gareth Jenkins, Swansea University

PhD Studentship

The snail assay as an alternative to the rodent Hershberger assay for detecting androgens and anti-androgens

Principal Investigator: Dr Susan Jobling, Brunel University

Project grant

Development and validation of mechanisms-based in vitro transformation assays for carcinogen screening

Principal Investigator: Professor Robert Newbold, Brunel University

Project grant

Development of a mechanistically informative genome-wide, replacement chemicals screening technology

Principal Investigator: Professor Andrew Cossins, University of Liverpool

Project grant

Metabolically competent stem cell systems: novel means to implement 3Rs in better drug safety assessment

Principal Investigator: Professor Roland Wolf, University of Dundee

Project grant