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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

55 results

Development of a mechanistically informative genome-wide, replacement chemicals screening technology

Principal Investigator: Professor Andrew Cossins, University of Liverpool

Project grant

Metabolically competent stem cell systems: novel means to implement 3Rs in better drug safety assessment

Principal Investigator: Professor Roland Wolf, University of Dundee

Project grant

The use of honeybees to screen for toxins

Principal Investigator: Dr Helen Thompson, Food and Environment Research Agency

Project grant

Development of a new human cell genotoxicity assay to reduce the use of live animals in drug development

Principal Investigator: Professor Richard Walmsley, University of Manchester

Project grant

Replacement of the mouse bioassay: Development of SPE and LC-MS for detection of paralytic shellfish poisoning toxins

Principal Investigator: Dr Elizabeth Turrell, Marine Scotland Science

Project grant

Cell lines for prediction of drug metabolism and toxicity in man

Principal Investigator: Professor Charles Wolf, Dundee Technopol CXR Biosciences Ltd

Project grant

Applying exposure science to increase the utility of non-animal data in efficacy and safety testing

Current contact: Dr Natalie Burden

Office-led project

Opportunities to apply the 3Rs in the safety assessment of nanomaterials

Current contact: Dr Natalie Burden

Office-led project

Utilising QSARs to predict fish acute toxicity of pesticide metabolites

Current contact: Dr Natalie Burden

Office-led project

Applying pathways-based approaches across the biosciences

Current contact: Dr Natalie Burden

Office-led project

Redundancy in the acute toxicity testing of chemicals

Current contact: Dr Natalie Burden

Office-led project

Pharmacokinetics in candidate selection

Current contact: Dr Fiona Sewell

Office-led project

Abuse potential studies

Current contact: Dr Nathalie Percie du Sert

Office-led project

In vitro approaches for carcinogenicity testing

Current contact: Dr Natalie Burden

Office-led project

Single dose acute toxicity studies

Current contact: Dr Fiona Sewell

Office-led project