Development of cell based assays as replacement assays for Botulinum toxins and antitoxins Principal Investigator: Dr Dorothea Sesardic, National Institute for Biological Standards and Control Project grant
Stem cell-derived cardiomyocytes for detection of cardiotoxicity in cancer therapeutics Principal Investigator: Professor Sian Harding, Imperial College London Project grant
A 3D tissue model of breast morphogenesis for replacing animals in testing for endocrine disrupting substances Principal Investigator: Professor Charles Vyvyan Howard, University of Ulster Project grant
The validation of defined genotoxic thresholds, leading to better in vitro risk assessments of carcinogenic potential Principal Investigator: Professor Gareth Jenkins, Swansea University PhD Studentship
The snail assay as an alternative to the rodent Hershberger assay for detecting androgens and anti-androgens Principal Investigator: Dr Susan Jobling, Brunel University Project grant
Development and validation of mechanisms-based in vitro transformation assays for carcinogen screening Principal Investigator: Professor Robert Newbold, Brunel University Project grant
Development of a mechanistically informative genome-wide, replacement chemicals screening technology Principal Investigator: Professor Andrew Cossins, University of Liverpool Project grant
Metabolically competent stem cell systems: novel means to implement 3Rs in better drug safety assessment Principal Investigator: Professor Roland Wolf, University of Dundee Project grant
The use of honeybees to screen for toxins Principal Investigator: Dr Helen Thompson, Food and Environment Research Agency Project grant
Development of a new human cell genotoxicity assay to reduce the use of live animals in drug development Principal Investigator: Professor Richard Walmsley, University of Manchester Project grant
Replacement of the mouse bioassay: Development of SPE and LC-MS for detection of paralytic shellfish poisoning toxins Principal Investigator: Dr Elizabeth Turrell, Marine Scotland Science Project grant
Cell lines for prediction of drug metabolism and toxicity in man Principal Investigator: Professor Charles Wolf, Dundee Technopol CXR Biosciences Ltd Project grant
Applying exposure science to increase the utility of non-animal data in efficacy and safety testing Current contact: Dr Natalie Burden Office-led project
Opportunities to apply the 3Rs in the safety assessment of nanomaterials Current contact: Dr Natalie Burden Office-led project
Utilising QSARs to predict fish acute toxicity of pesticide metabolites Current contact: Dr Natalie Burden Office-led project
Applying pathways-based approaches across the biosciences Current contact: Dr Natalie Burden Office-led project
Redundancy in the acute toxicity testing of chemicals Current contact: Dr Natalie Burden Office-led project
In vitro approaches for carcinogenicity testing Current contact: Dr Natalie Burden Office-led project