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Topic

Model

Impact stories

631 results

Refining the tagging of wild fish and sharks

Principal Investigator: Dr Matthew Witt, University of Exeter

PhD Studentship

Dr Matthew Witt with two boats on grass in the background

Understanding how altered brain metabolism causes mitochondrial disease

Principal Investigator: Dr Joseph Bateman, King's College London

PhD Studentship

Combining a fully synthetic hydrogel with human intestinal organoids to model pathological matrix remodelling in Inflammatory Bowel Disease

Principal Investigator: Professor Eileen Gentleman, King's College London

PhD Studentship

3D bioprinted microtissues to develop patient-specific non-animal technologies (NAT) in cancer drug development

Principal Investigator: Dr Deepali Pal, Northumbria University

PhD Studentship

Deepali Pal using a microscope. A colleague is beside her looking at a screen

Insects as models to study wound healing, infection and the wound microbiome

Principal Investigator: Dr Ronan McCarthy, Brunel University

PhD Studentship

A 3Rs approach to investigate the feto-maternal interface: visualisation of pathogen and antibody in a 3D in vitro human placental model

Principal Investigator: Professor Aras Kadioglu, University of Liverpool

PhD Studentship

Development and validation of 3D in vitro dormant myeloma cell models to reduce and replace animal studies

Principal Investigator: Dr Michelle Lawson, University of Sheffield

PhD Studentship

Live monitoring of foreign-body response in animals by diffuse Raman spectroscopy

Principal Investigator: Professor Ioan Notingher, University of Nottingham

Project grant

Development of a New Human Model of Lung Squamous Cell Carcinoma Progression

Principal Investigator: Dr Carlos Lopez-Garcia, University of Manchester

Project grant

Establishing the novel ex-vivo focal demyelination model of Multiple Sclerosis in other laboratories to reduce and replace live animal use

Principal Investigator: Dr Ben Newland, Cardiff University

Skills and Knowledge Transfer grant

Adoption of a mouse model of veterinary filariasis for preclinical drug testing

Principal Investigator: Dr Joseph Turner, Liverpool School of Tropical Medicine

Skills and Knowledge Transfer grant

A novel Drosophila model of chronic inflammatory lung disease to explore airway damage, inflammation and infection in vivo

Principal Investigator: Dr Helen Weavers, University of Bristol

PhD Studentship

Determining the efficacy and safety of cancer chemotherapeutics for cholangiocarcinoma (CCA) using Human Precision Cut Tissue Slices (hPCTS)

Principal Investigator: Dr Laura Randle, Unviversity of Liverpool

Skills and Knowledge Transfer grant

Using a novel, high welfare in vivo feeding device for poultry red mite and its integration with other novel tools for this parasite

Principal Investigator: Dr Alasdair Nisbet, Moredun Research Institute

Skills and Knowledge Transfer grant

Go North: Expanding the use of the chick embryo model in cancer research to a multiuser facility at the University of Strathclyde

Principal Investigator: Dr Marie Boyd, University of Strathclyde

Skills and Knowledge Transfer grant

A non-protected larval zebrafish model for the investigation of novel strategies to protect against nerve agent-induced toxicity and seizures

Principal Investigator: Dr Matthew Parker, University of Portsmouth

Skills and Knowledge Transfer grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Review of animal use requirements in WHO biologics guidelines

Current contact: Dr Elliot Lilley

Office-led project

Acquisition of the Drosophila model system to understand mechanisms of innate immunity regulation by chromatin dynamics

Principal Investigator: Dr Patrick Varga-Weisz, University of Essex

Skills and Knowledge Transfer grant

Cerebral organoid models for optical investigation of neural circuit dynamics in neurodegenerative diseases

Principal Investigator: Professor Simon Schultz, Imperial College London

Skills and Knowledge Transfer grant

Replacing in vivo models with the Quasi vivo system to investigate metastatic site priming by tumour cells

Principal Investigator: Dr Hannah Harrison, University of Manchester

Skills and Knowledge Transfer grant