Search our 3Rs resource library

Use the filters below to narrow down our resources to those relevant to your role, the model you are interested in, or by topic area. Filters are best used by combining two or more to narrow down the results.

Audience

Resource type

Resource topic

Model

83 results

Example enrichment study protocols

Guidance on how to conduct an evaluation of environmental enrichment.

Guidance

Developments and future directions in regulatory fish acute toxicity testing

Webinar showcasing ongoing and novel initiatives that replace, reduce and/or refine fish acute toxicity studies.

Webinar and video

Housing and husbandry: Rabbit

Information to help refine the housing and husbandry of the laboratory rabbit.

Guidance

Two white rabbits in a floor pen. The cage is grey and you can see sawdust and straw on the floor. The closest rabbit is sitting on a raised ledge looking towards a food hopper which contains hay and carrots. The other rabbit can be seen exploring the floor towards the back.

Housing and husbandry: Cat

Information to help refine the housing and husbandry of the laboratory cat.

Guidance

A technician with cats in a play area. The technician is wearing a white protective suit, mask, hair net and laboratory gloves. She is holding a piece of string which one of the cats is rearing up to play with. One cat sits on a shelf to the left, another is walking along the floor looking at the camera.

Housing and husbandry: Rat

Information to help refine the housing and husbandry of the laboratory rat.

Guidance

A rat accepting a treat, in this case a cereal cheerio snack, from a technician. The rat sits on top of a housing box within a cage (the lid is open). The technician is reaching in with a gloved hand, and the black and white lister hooded rat is reaching up to take the treat.

Rat playpens

The positive impact playpens have on laboratory rat welfare, and guidance on how to set one up in your institution.

Guidance

A tall cage which has been used to create a rat playpen. There are three different tiers with ladders to allow the rats to climb up between each one. A number of white rats can be seen moving between the different levels. Enrichment and play objects are available on each level including an cardboard box that used to hold laboratory gloves, coloured balls, tubes, a wheel and a raised platform on the top level with some bedding material.

Housing and husbandry: Guinea pig

Information to help refine the housing and husbandry of the laboratory guinea pig.

Guidance

White guinea pigs in floor pen. Each enclosure holds around three to five guinea pigs and is separated with clear perspex partitions so the animals can see each other. Each enclosure has a silver box to create shade and shelter. The floor is covered in sawdust and straw.

Sharing and archiving of GA mice

Guidance document on opportunities to reduce and refine the use of GA mice through cryopreservation and sharing.

Guidance

The front cover of the "Sharing & archiving of genetically altered mice" document on a green background.

Acute toxicity testing

Reducing and refining acute toxicity tests in the pharmaceutical and chemicals industries.

Guidance

A white mouse on a technician's gloved hands

Environmental safety testing

Providing an evidence base to refine and reduce the use of vertebrates in (regulatory) ecotoxicology studies

Guidance

Exposure and dose selection

Using exposure science to refine and reduce animal use, and support the uptake of new approach methodologies

Guidance

A lister hooded rat (black head white body) seen in a standard rat housing cage. The rat is standing on a plastic box and is looking out of the open cage lid.

New approach methodologies (NAMs) in toxicology

Supporting the uptake of new approach methodologies to reduce reliance on traditional animal toxicity tests

Guidance

A cell culture plate containing pink liquid under a microscope. A gloved hand is holding the plate while another is pipetting liquid into it.

Safety pharmacology

Guidance on reducing or refining animal use for studies with cardiovascular, central nervous system and respiratory functional measurements.

Guidance

Study designs for pharmaceutical and chemical development

Projects providing guidance to reduce animal use or refine procedures within toxicology studies.

Guidance

An orange gloved hand holds a pipette above a row of other pipettes on a lab bench.

External link

Environmental monitoring for rodent health surveillance

A webinar exploring how environmental monitoring can replace the use of sentinel animals for monitoring mouse colonies for the presence of pathogens.

Webinar and video

Webinar title slide: Environmental monitoring for rodent health surveillance

External link

Assessing the genotoxic potential of gene therapy products in vitro

10 years of CRACK IT webinar: The Human In Vitro Gene Therapy Genotoxicity Testing service.

Webinar and video

Housing and husbandry: Hamster

Information to help refine the housing and husbandry of the laboratory hamster.

Guidance

Two hamsters in a cage. The floor is covered in sawdust. One hamster is towards the right hand side, the other is in the middle, emerging from a cardboard tube (enrichment). Both hamsters are red and light brown in colour.

Housing and husbandry: Mouse

Information to help refine the housing and husbandry of the laboratory mouse.

Guidance

Housing and husbandry: Dog

Information to help refine the housing and husbandry of the laboratory dog.

Guidance

Four dogs in a pen, interacting and showing amicable social behaviour. The two dogs in the background are nose to nose. In the foreground one dog is on his back with legs in the air, a second dog can be seen sniffing him from the side.

External link

Malocclusion in mice: Spot the signs and take action

A video to be used for training and education, to improve mouse welfare within a research setting.

Webinar and video

Malocclusion in mice

Information and resources on malocclusion in mice to improve welfare within a research setting.

Guidance | Hard copy

One mouse exhibiting healthy teeth and another exhibiting unhealthy, maloccluded teeth

Training on the 3Rs

A video resource for introductory training on the 3Rs aimed at in vivo researchers and animal technicians.

E-learning | Webinar and video

Cover slide for the 3Rs training webinar. The title of the talk is seen in white text on a blue background - The 3Rs: Their definition, application and importance to your work.

Rat tickling

Resources on rat tickling and how it can be used to promote positive human-animal interactions.

Overview

A white rat in a clear plastic cage with wooden shavings, being tickled by a gloved hand.

Rat tickling: Certification

An online course created allowing you to become certified in the correct rat tickling technique.

E-learning

A white rat being tickled by an ungloved hand. The rat is lying on its back on sawdust within its cage.