Guidance document on opportunities to reduce and refine the use of GA mice through cryopreservation and sharing.
Reducing and refining acute toxicity tests in the pharmaceutical and chemicals industries.
Providing an evidence base to refine and reduce the use of vertebrates in (regulatory) ecotoxicology studies
Using exposure science to refine and reduce animal use, and support the uptake of new approach methodologies
Supporting the uptake of new approach methodologies to reduce reliance on traditional animal toxicity tests
Guidance on reducing or refining animal use for studies with cardiovascular, central nervous system and respiratory functional measurements.
Projects providing guidance to reduce animal use or refine procedures within toxicology studies.
10 years of CRACK IT webinar: The Human In Vitro Gene Therapy Genotoxicity Testing service.
A webinar exploring how environmental monitoring can replace the use of sentinel animals for monitoring mouse colonies for the presence of pathogens.
A webinar series from a cross-European group of 3Rs centres exploring the challenges and opportunities of replacing BMEs.
Information to help refine the housing and husbandry of the laboratory hamster.
The evidence supporting the use of tunnel and cup handling to improve animal welfare and scientific outcomes (presented at AALAS 2021).
Information to help refine the housing and husbandry of the laboratory mouse.
Details of the Mouse Grimace Scale, including a poster for display in laboratory rooms and corridors.
Details of the Rat Grimace Scale, including a poster for display in laboratory rooms and corridors.
10 years of CRACK IT webinar: An IVF micro microfluidic device for non-surgical embryo transfer to generate transgenic mice.
Information to help refine the housing and husbandry of the laboratory dog.
Tips to avoid common pitfalls when describing your experimental design and methodology in a funding proposal.
An online tool to guide researchers through designing experiments involving the use of animals.
A dedicated, open access portal for our Grant holders to showcase their 3Rs research.
An introduction to systematic reviews, a powerful method used to assess accumulating evidence related to a specific research question.
Reporting guidelines for animal experiments, and additional resources to support their use.
Reasons for conducting a pilot study and what you can do with the results.
10 years of CRACK IT webinar: A physiological-competent and predictive human 3D retinal cell model.