Guidance document on opportunities to reduce and refine the use of GA mice through cryopreservation and sharing.
Guidance on best practices in confirming, archiving and maintaining strains, as well as re-establishing colonies after a pause.
Links to mouse databases and resources to support good colony management.
Answers to some of the most often asked questions on breeding and maintaining GA mouse colonies.
A joint NC3Rs/Mary Lyon Centre webinar on applying best practice to get the most out of the minimum number of animals.
Archiving can provide a back-up to production colonies, minimise genetic drift, reduce the need for tick-over colonies and preserve valuable models.
Intermittent breeding should be used instead of constant mating to avoid unnecessary wastage of animals, whilst retaining the ability to breed an
Specifically around re-starting breeding and animal experiments after a pause (e.g. work with mice after the COVID-19 lockdown).
Definition of key terms used in breeding and colony management.
A high level introduction to best practice in mouse colony management, including confirming, archiving and maintaining mouse strains.
For answers to more specific questions about colony management or breeding difficult strains you can email our dedicated advice service.
It starts at the very beginning: Scientific and welfare reasons for reviewing neonate care
F0-ols Rush In: Improving reproducibility and avoiding genetic mosaicism using CRISPR/Cas9 technology.
A discussion on the possible impact of genetic drift on the integrity of the data from GA mouse studies
Watch your Back! The importance of background strain.
A discussion of the animal welfare challenges around the generation of GA mice, and strategies for improving welfare.