Testing and validation of an in vitro 3D human chondrocyte model to replace animal use in mechanobiology research Principal Investigator: Dr Emma Blain, Cardiff University Grants
Embryonic zebrafish models of HACD1-deficiency to replace mammals in congenital myopathy and lipidomic research Principal Investigator: Dr Gemma Walmsley, University of Liverpool PhD Studentship
Investigation of dopamine transporter dysfunction linked to DAT/SLC6A3 mutations in CRISPR-Cas engineered C. elegans and patient derived iPCSs Principal Investigator: Dr Eva Kevei, University of Reading PhD Studentship
Modulating Macrophage Phenotypes During Infection In Zebrafish Principal Investigator: Dr Phillip Elks, University of Sheffield PhD Studentship
Developing gene editing technologies in the non-mammalian infectious disease model organism, Galleria mellonella Principal Investigator: Dr James Pearce, University of Exeter Fellowship
A 3Rs platform for glial research: From animal to human to in-silico models Principal Investigator: Professor Dmitri Rusakov, University College London Project grant
High fidelity computational approaches to exploit new structures of cardiac ion channels Principal Investigator: Dr Andrew Leach, University of Manchester PhD Studentship
Drosophila based screening to replace mammalian systems to identify the functional role of candidate genes in controlling muscle dyadic architecture Principal Investigator: Professor Andrew Trafford, University of Manchester PhD Studentship
Development of endometrial/myometrial organoids to study disorders of pregnancy and parturition Principal Investigator: Dr Andrew Blanks, University of Warwick Project grant
Refining in vivo studies of cancer metastasis with next-generation explant-in-chip perfusion models Principal Investigator: Professor Darryl Overby, Imperial College London Project grant
Developing a stem-cell prostate organoid model - reducing global animal usage in prostate development and cancer studies Principal Investigator: Dr Adriana Buskin, Newcastle University Fellowship
Modelling of thrombus dynamics in a microfluidic 'vasculature' Principal Investigator: Dr Nicola Mutch, University of Aberdeen PhD Studentship
Long-term, self-maintaining primary 3D cultures of mouse and human epithelial tissues for reduction and replacement of animals in research Principal Investigator: Dr David Fernandez-Antoran, University of Cambridge Skills and Knowledge Transfer grant
The application of trabecular bone organoids to investigate mineral-sensing in skeletal physiology and disease Principal Investigator: Dr Alexandra Iordachescu, University of Birmingham Skills and Knowledge Transfer grant
Characterisation of Galleria mellonella innate immune response to Mycobacterium tuberculosis infection Principal Investigator: Dr Masanori Asai, Imperial College London Fellowship
Accelerating the uptake of non-animal derived antibodies Current contact: Dr Rachel Eyre, Office-led project
Exploring the role of matrix encapsulation on early developmental decisions using non-animal sourced hydrogels Principal Investigator: Professor Cathy Merry, University of Nottingham PhD Studentship
3D patient-derived organoids: A viable and complementary model to study neural system dysfunction in Alzheimer's Disease Principal Investigator: Dr Marc Busche, University College London PhD Studentship
Efficacy of artificial imprinted antibodies in driving unwarranted immune responses Principal Investigator: Dr Shoba Amarnath, Newcastle University PhD Studentship