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Activity type

Topic

Model

Impact stories

631 results

Testing and validation of an in vitro 3D human chondrocyte model to replace animal use in mechanobiology research

Principal Investigator: Dr Emma Blain, Cardiff University

Project grant

Improving preclinical proton radiation dosimetry using a biologically relevant murine dosimetry phantom

Principal Investigator: Miss Emma Biglin, University of Manchester

Fellowship

Rows of PCR tubes on a yellow background

Embryonic zebrafish models of HACD1-deficiency to replace mammals in congenital myopathy and lipidomic research

Principal Investigator: Dr Gemma Walmsley, University of Liverpool

PhD Studentship

Investigation of dopamine transporter dysfunction linked to DAT/SLC6A3 mutations in CRISPR-Cas engineered C. elegans and patient derived iPCSs

Principal Investigator: Dr Eva Kevei, University of Reading

PhD Studentship

Modulating Macrophage Phenotypes During Infection In Zebrafish

Principal Investigator: Dr Phillip Elks, University of Sheffield

PhD Studentship

Developing gene editing technologies in the non-mammalian infectious disease model organism, Galleria mellonella

Principal Investigator: Dr James Pearce, University of Exeter

Fellowship

Refining mouse glucose homeostasis assessments

Principal Investigator: Professor Kate Ellacott, University of Exeter

Skills and Knowledge Transfer grant

A 3Rs platform for glial research: From animal to human to in-silico models

Principal Investigator: Professor Dmitri Rusakov, University College London

Project grant

High fidelity computational approaches to exploit new structures of cardiac ion channels

Principal Investigator: Dr Andrew Leach, University of Manchester

PhD Studentship

Drosophila based screening to replace mammalian systems to identify the functional role of candidate genes in controlling muscle dyadic architecture

Principal Investigator: Professor Andrew Trafford, University of Manchester

PhD Studentship

Ensuring humane deaths for laboratory birds

Principal Investigator: Dr Jessica Martin, Newcastle University

PhD Studentship

Development of endometrial/myometrial organoids to study disorders of pregnancy and parturition

Principal Investigator: Dr Andrew Blanks, University of Warwick

Project grant

Replacement in vivo preclinical models to substantially refine and reduce severe protocols used in snakebite envenoming research

Principal Investigator: Dr Stuart Ainsworth, University of Liverpool

Project grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Refining in vivo studies of cancer metastasis with next-generation explant-in-chip perfusion models

Principal Investigator: Professor Darryl Overby, Imperial College London

Project grant

Developing a stem-cell prostate organoid model - reducing global animal usage in prostate development and cancer studies

Principal Investigator: Dr Adriana Buskin, Newcastle University

Fellowship

Modelling of thrombus dynamics in a microfluidic 'vasculature'

Principal Investigator: Dr Nicola Mutch, University of Aberdeen

PhD Studentship

Portrait of Dr Whyte and Professor Mutch

RIVER Recommendations

Current contact: James Barker

Office-led project

Four bottles of culture medium, in a laboratory setting.

Long-term, self-maintaining primary 3D cultures of mouse and human epithelial tissues for reduction and replacement of animals in research

Principal Investigator: Dr David Fernandez-Antoran, University of Cambridge

Skills and Knowledge Transfer grant

Grant holder David Fernandez-Antoran sitting at a computer displaying an image of cells.

The application of trabecular bone organoids to investigate mineral-sensing in skeletal physiology and disease

Principal Investigator: Dr Alexandra Iordachescu, University of Birmingham

Skills and Knowledge Transfer grant

Characterisation of Galleria mellonella innate immune response to Mycobacterium tuberculosis infection

Principal Investigator: Dr Masanori Asai, Imperial College London

Fellowship