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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

462 results

Understanding how altered brain metabolism causes mitochondrial disease

Principal Investigator: Dr Joseph Bateman, King's College London

PhD Studentship

Combining a fully synthetic hydrogel with human intestinal organoids to model pathological matrix remodelling in Inflammatory Bowel Disease

Principal Investigator: Professor Eileen Gentleman, King's College London

PhD Studentship

3D bioprinted microtissues to develop patient-specific non-animal technologies (NAT) in cancer drug development

Principal Investigator: Dr Deepali Pal, Northumbria University

PhD Studentship

Deepali Pal using a microscope. A colleague is beside her looking at a screen

Insects as models to study wound healing, infection and the wound microbiome

Principal Investigator: Dr Ronan McCarthy, Brunel University

PhD Studentship

A 3Rs approach to investigate the feto-maternal interface: visualisation of pathogen and antibody in a 3D in vitro human placental model

Principal Investigator: Professor Aras Kadioglu, University of Liverpool

PhD Studentship

Development and validation of 3D in vitro dormant myeloma cell models to reduce and replace animal studies

Principal Investigator: Dr Michelle Lawson, University of Sheffield

PhD Studentship

Development of a New Human Model of Lung Squamous Cell Carcinoma Progression

Principal Investigator: Dr Carlos Lopez-Garcia, University of Manchester

Project grant

Establishing the novel ex-vivo focal demyelination model of Multiple Sclerosis in other laboratories to reduce and replace live animal use

Principal Investigator: Dr Ben Newland, Cardiff University

Partnerships and impact awards

A novel Drosophila model of chronic inflammatory lung disease to explore airway damage, inflammation and infection in vivo

Principal Investigator: Dr Helen Weavers, University of Bristol

PhD Studentship

Determining the efficacy and safety of cancer chemotherapeutics for cholangiocarcinoma (CCA) using Human Precision Cut Tissue Slices (hPCTS)

Principal Investigator: Dr Laura Randle, Unviversity of Liverpool

Partnerships and impact awards

Go North: Expanding the use of the chick embryo model in cancer research to a multiuser facility at the University of Strathclyde

Principal Investigator: Dr Marie Boyd, University of Strathclyde

Partnerships and impact awards

A non-protected larval zebrafish model for the investigation of novel strategies to protect against nerve agent-induced toxicity and seizures

Principal Investigator: Dr Matthew Parker, University of Portsmouth

Partnerships and impact awards

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Review of animal use requirements in WHO biologics guidelines

Current contact: Dr Elliot Lilley

Office-led project

Acquisition of the Drosophila model system to understand mechanisms of innate immunity regulation by chromatin dynamics

Principal Investigator: Dr Patrick Varga-Weisz, University of Essex

Partnerships and impact awards

Cerebral organoid models for optical investigation of neural circuit dynamics in neurodegenerative diseases

Principal Investigator: Professor Simon Schultz, Imperial College London

Partnerships and impact awards

Replacing in vivo models with the Quasi vivo system to investigate metastatic site priming by tumour cells

Principal Investigator: Dr Hannah Harrison, University of Manchester

Partnerships and impact awards

Generation of functionally mature pancreatic organoids as a replacement strategy for animal-models of pancreatitis and pancreatic cancer

Principal Investigator: Dr Jean-Francois Darrigrand, King's College London

Fellowship

Dr Jean-Francois Darrigrand in a white lab coat

Forced swim test in rodents

Current contact: Dr Vicky Robinson

Office-led project

Understanding brain regeneration in a zebrafish larval model of intracerebral haemorrhage

Principal Investigator: Dr Siobhan Crilly, University of Manchester

Fellowship

Investigating biomechanical responses in healthy and diseases ageing cartilage - a tissue engineering approach

Principal Investigator: Dr Katarzyna Pirog, Newcastle University

PhD Studentship