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Activity type

Topic

Model

Impact stories

425 results

A living biobank of post-surgical residual glioblastoma to replace animal studies

Principal Investigator: Dr Spencer Collis, University of Sheffield

PhD Studentship

Development of an in vitro model to dissect the mechanism of fungal persistence in the cystic fibrosis lung

Principal Investigator: Professor Paul Bowyer, University of Manchester

PhD Studentship

Use of induced pluripotent stem cell derived cardiomyocytes to test the consequences of genetic variants in atrial and ventricular arrhythmias

Principal Investigator: Dr Katja Gehmlich, University of Birmingham

PhD Studentship

Two headshots side by side. On the left is Max, on the right is Dr Katja Gehmlich

MacuSIM: A microfluidic, in vitro model of the outer retina as an experimental platform for macular disease and therapeutic trials

Principal Investigator: Dr Savannah Lynn, University of Southampton

Fellowship

A novel tool that embeds 3Rs principles in multiple sclerosis research

Principal Investigator: Dr Julia Edgar, University of Glasgow

PhD Studentship

Validating CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes as tools to assist with toxicity profiling, adverse drug reaction notices and black box warnings

Principal Investigator: Professor Chris Denning, University of Nottingham

Technologies to Tools grant

A computational framework to investigate the mechanical role of the extracellular matrix in tissue development and disease

Principal Investigator: Dr Nargess Khalilgharibi, University College London

Fellowship

A novel embryonic zebrafish model to replace mammals in the study of 3-hydroxyacyl CoA dehydratase 1-associated muscle disorders

Principal Investigator: Dr Rhiannon Morgan, University of Liverpool

Fellowship

Modelling O-GlcNAc transferase intellectual disability syndrome in Drosophila

Principal Investigator: Professor Daan van Aalten, University of Dundee

PhD Studentship

Engineering Galleria Mellonella as a model for infection, immunity and inflammation

Principal Investigator: Dr James Wakefield, University of Exeter

Project grant

CleanCut: Developing a human in vitro model to assess the safety of gene edited human haemopoietic stem cells

Contractor: Dr Alessandro Rotilio, MOAB srl

CRACK IT Challenge

A novel Drosophila platform to replace the use of mice and zebrafish for the study of ER-mitochondria interactions

Principal Investigator: Dr Alessio Vagnoni, King's College London

Skills and Knowledge Transfer grant

Developing a chick embryo model to aid in development of personalised therapies for malignant pleural mesothelioma

Principal Investigator: Professor Judy Coulson, University of Liverpool

Project grant

Focused molecular understanding of hypertrophic cardiomyopathy using CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes

Principal Investigator: Dr Diogo Mosqueira, University of Nottingham

Fellowship

Development of an invertebrate model of alternating hemiplegia of childhood

Principal Investigator: Dr Steven Clapcote, University of Leeds

PhD Studentship

Development and characterization of a novel endothelialized in vitro model of human atherothrombosis

Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University

PhD Studentship

An organotypic model of the bone remodelling process

Principal Investigator: Dr Amy Naylor, University of Birmingham

PhD Studentship

A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model

Principal Investigator: Dr Adrian Biddle, Queen Mary University of London

PhD Studentship

Modelling Candida albicans infection of the human gut using human intestinal organoid cultures

Principal Investigator: Dr Silvia Gratz, University of Aberdeen

PhD Studentship

Maternal immune activation: advancing from rodents to humans through a development of a hIPSC model to study gene x environment interactions

Principal Investigator: Dr Anthony Vernon, King's College London

PhD Studentship