Search our 3Rs resource library

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181 results

The importance of neonate assessment

It starts at the very beginning: Scientific and welfare reasons for reviewing neonate care

Guidance

A litter of black mice with an adult mouse, nesting in the corner of their home cage

Analgesia

General principles in analgesia to support best practice.

Guidance

A rabbit not exhibiting any signs of pain

Key elements of a well-designed experiment

Things to consider when designing your animal experiments.

Guidance

a mouse taking a food pellet form a metal feeder

CRISPR/Cas9 technology

F0-ols Rush In: Improving reproducibility and avoiding genetic mosaicism using CRISPR/Cas9 technology.

Guidance

A white icon of the DNA double helix on a purple background.

Microsampling study designs

Examples of study designs that may be used for microsampling from either main study animals or from satellite groups of animals.

Guidance

A lister hooded rat (black head white body) being held by a technician. The technician wears a green gown and purple gloves.

Genetic drift in GA mouse studies

A discussion on the possible impact of genetic drift on the integrity of the data from GA mouse studies

A white and grey mother mouse with pups of varying shades from white to black in their home cage

The importance of background strains in GA mice

Watch your Back! The importance of background strain.

Two pale brown and white chimeric mice standing on top of food pellets.

Generation and breeding of genetically altered mice

A discussion of the animal welfare challenges around the generation of GA mice, and strategies for improving welfare.

A chimeric mouse, identifiable from its dappled or spotted two colored coat, in this case white and black.

Housing and husbandry: Non-human primate

Information to help refine the housing and husbandry of laboratory non-human primates.

Guidance

A large room housing a breeding group of rhesus macaques. In the background is a floor-to-ceiling height bay window, letting lots of natural light into the room. The floor is covered in a deep layer of wood shavings, with one monkey on the floor foraging for scattered food. Wooden ladders, platforms and shelves fill the walls and room space, some of which have monkeys resting on them. Suspended from the ceiling are swings made from wood and ropes, and from plastic barrels and firehoses.

Training animals

Guidance on implementing positive reinforcement training methods.

Guidance

Marmoset being handfed as part of positive reinforcement training

Welfare assessment

General principles for welfare assessments.

Guidance

A technician in a green gown, mask and hair net can be seen alongside racks of mouse cages. He can be seen reaching into one of the cages to check on the health of a mouse.

Chronic Implants Wiki

Wiki on refinement of the use of chronic implants in neuroscience research using non-human primates. DISCONTINUED.

Guidance

Refining food and fluid control in macaques

Guidelines on the use of food and fluid control in behavioural neuroscience.

Guidance

A macaque sits in its homecage on top of a plastic pipe holding a rope