A discussion of the animal welfare challenges around the generation of GA mice, and strategies for improving welfare.
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Answers to some of the most often asked questions on breeding and maintaining GA mouse colonies.
Guidance document on opportunities to reduce and refine the use of GA mice through cryopreservation and sharing.
Links to mouse databases and resources to support good colony management.
Intermittent breeding should be used instead of constant mating to avoid unnecessary wastage of animals, whilst retaining the ability to breed an
Watch your Back! The importance of background strain.
Definition of key terms used in breeding and colony management.
It starts at the very beginning: Scientific and welfare reasons for reviewing neonate care
F0-ols Rush In: Improving reproducibility and avoiding genetic mosaicism using CRISPR/Cas9 technology.
Specifically around re-starting breeding and animal experiments after a pause (e.g. work with mice after the COVID-19 lockdown).
A high level introduction to best practice in mouse colony management, including confirming, archiving and maintaining mouse strains.
A joint NC3Rs/Mary Lyon Centre webinar on applying best practice to get the most out of the minimum number of animals.
Practical advice on calculating how many matings to set up, including available breeding calculator tools.
Archiving can provide a back-up to production colonies, minimise genetic drift, reduce the need for tick-over colonies and preserve valuable models.
Guidance on best practices in confirming, archiving and maintaining strains.
A discussion on the possible impact of genetic drift on the integrity of the data from GA mouse studies
