Replacement, Reduction and Refinement
Guidelines, practical information, publications, video and training materials to help you put the 3Rs into practice.
We fund world class researchers to develop predictive, reliable and humane 3Rs approaches.
Details of NC3Rs projects, including grants, early career awards and work led by our staff.
What are the 3Rs? How many animals are used in research? Find answers to these questions and more.
Latest news
Explore the evolving relationship between genetic modification and the 3Rs over the past two decades in our article in the Genetics Society magazine.
Analysis led by the NC3Rs aims to inform new endocrine disruption testing requirements in the EU to avoid substantially increasing animal use and resource.
Our total commitment for project grants over the past twenty years has now surpassed £50M, supporting 3Rs method development, characterisation and dissemination.
Our Experimental Design Assistant (EDA) helps you to design robust and meaningful animal experiments. With a wealth of information, features and tools, here are our tips to help you make the most of the EDA.
An in vitro assay to test follicle-stimulating hormone potency has been recognised in the annual NC3Rs Prize which is co-funded by GSK.
In collaboration with the Only Good Antibodies community we are improving the integrity and reproducibility of biomedical research that relies on commercial antibodies.
Discover 3Rs innovations from the NC3Rs
Bringing together expertise from different sectors and disciplines to deliver readily available and easily deployed 3Rs models and tools that are more predictive and cost-effective than current animal models.
