Genetically altered mice

Here we collate general information to help with the implementation of approaches to reduce and refine the use of genetically alteredĀ (GA) mice.

Improving reproducibility and avoiding genetic mosaicism using CRISPR/Cas9 technology
Ways to improve animal welfare
A discussion on the possible impact of genetic drift on the integrity of the data from GA mouse studies
Scientific and welfare reasons for reviewing neonate care
Comparing the technical performances of background strains
Links to mouse databases and resources to support good colony management
Opportunities for reduction and refinement (downloads a PDF).
The importance of background strain