Genetically altered mice

Here we collate general information to help with the implementation of approaches to reduce and refine the use of genetically alteredĀ (GA) mice.

Guidance on re-establishing colonies after a pause (e.g. COVID-19 lockdown) with an emphasis on minimising the number of mice used.
Improving reproducibility and avoiding genetic mosaicism using CRISPR/Cas9 technology.
Ways to improve animal welfare.
A discussion on the possible impact of genetic drift on the integrity of the data from GA mouse studies.
Scientific and welfare reasons for reviewing neonate care .
Comparing the technical performances of background strains.
Links to mouse databases and resources to support good colony management.
Updated guidance on opportunities for reduction and refinement.
The importance of background strain.