Here we collate general information to help with the implementation of approaches to reduce and refine the use of genetically altered (GA) mice.
Guidance on re-establishing colonies after a pause (e.g. COVID-19 lockdown) with an emphasis on minimising the number of mice used.
Improving reproducibility and avoiding genetic mosaicism using CRISPR/Cas9 technology.
Ways to improve animal welfare.
Opportunities for reduction and refinement (downloads a PDF).