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With a decade of NC3Rs funding, scientists at the University of Birmingham have developed the first mature bone organotypic model, then systematically adapted and modified it to replace the use of rodents across a range of therapeutic areas involving the study of bone growth and regeneration.

Dr Karl Butterworth and PhD Student Dr Kathryn Brown have applied high precision cancer radiotherapy techniques used to treat human patients to improve the reproducibility and translatability of preclinical animal trials.