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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

425 results

A novel in silico framework for early mammalian embryo development

Principal Investigator: Dr David Richards, University of Exeter

Project grant

Developing a next generation in vitro 3D immune organoids system for studying vaccine-induced immune response and immune-ageing across the life-course

Principal Investigator: Dr Qibo Zhang, University of Surrey

Project grant

Understanding mechanisms driving lung disease caused by environmental particulate matter

Principal Investigator: Dr Nicholas Hannan, University of Nottingham

Project grant

SAFE: Developing a suite of innovative bioassays to replace in vivo fish studies in chemical safety screening and regulatory environmental risk assessment.

Contractor: Dr Stephan Fischer, aQuaTox-Solutions GmbH

CRACK IT Challenge

Development of an in vitro system that mimics B and T helper cell responses in porcine lymph nodes

Principal Investigator: Dr Wilhelm Gerner, The Pirbright Institute

Project grant

Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research

Principal Investigator: Dr Marko Nikolić, University College London

PhD Studentship

A high-throughput-compatible animal-cell-free miniaturised thymic organoid model for thymus biology studies and in vitro T cell production

Principal Investigator: Professor Clare Blackburn, University of Edinburgh

Project grant

Production of a Human Growth Plate Organ-Chip Model of Skeletal Development

Principal Investigator: Professor Martin Knight, Queen Mary University of London

Project grant

Photograph of Professor Martin Knight's lab group, from left to right, Dr Joanne Nolan (Centre Scientist, QM+Emulate Organs-on-Chips Centre), Dr Timothy Hopkins (named researcher), Prof. Martin Knight (PI), Dr Angus Wann (Co-I).

In vitro digestibility - reducing animal use whilst meeting the demand to evaluate alternative proteins

Principal Investigator: Professor John Brameld, University of Nottingham

Project grant

A collection of test tubes containing coloured liquid

Developing a complex in vitro airway model to study respiratory viral pathogenesis, lung macrophage function and herpesviral vaccine vectors in pigs

Principal Investigator: Dr Gyorgy Fejer, University of Plymouth

Project grant

Developing a human vascularised pancreatic islet on a chip - VIOC

Principal Investigator: Dr Victoria Salem, Imperial College London

Project grant

Novel in vitro platform to study molecular mechanisms of neurotransmitter release and synaptic plasticity

Principal Investigator: Professor Kirill Volynski, University College London

Project grant

Testing and validation of an in vitro 3D human chondrocyte model to replace animal use in mechanobiology research

Principal Investigator: Dr Emma Blain, Cardiff University

Project grant

Embryonic zebrafish models of HACD1-deficiency to replace mammals in congenital myopathy and lipidomic research

Principal Investigator: Dr Gemma Walmsley, University of Liverpool

PhD Studentship

Investigation of dopamine transporter dysfunction linked to DAT/SLC6A3 mutations in CRISPR-Cas engineered C. elegans and patient derived iPCSs

Principal Investigator: Dr Eva Kevei, University of Reading

PhD Studentship

Modulating Macrophage Phenotypes During Infection In Zebrafish

Principal Investigator: Dr Phillip Elks, University of Sheffield

PhD Studentship

Developing gene editing technologies in the non-mammalian infectious disease model organism, Galleria mellonella

Principal Investigator: Dr James Pearce, University of Exeter

Fellowship

A 3Rs platform for glial research: From animal to human to in-silico models

Principal Investigator: Professor Dmitri Rusakov, University College London

Project grant

High fidelity computational approaches to exploit new structures of cardiac ion channels

Principal Investigator: Dr Andrew Leach, University of Manchester

PhD Studentship

Drosophila based screening to replace mammalian systems to identify the functional role of candidate genes in controlling muscle dyadic architecture

Principal Investigator: Professor Andrew Trafford, University of Manchester

PhD Studentship