The human tumour micro-environment modelled in in vitro biomatrices and applied to cancer drug discovery Principal Investigator: Dr Anna Grabowska, University of Nottingham Project grant
iPS cells from ALS patients: Towards replacing animal models for ALS Principal Investigator: Dr Vasanta Subramanian, University of Bath Project grant
Refinement of animal studies on emesis by defining human biomarkers of nausea Principal Investigator: Professor Qasim Aziz, Queen Mary University of London Project grant
Replacement in vitro assays for the quantification of clostridial vaccine antigens Principal Investigator: Dr Keith Redhead Project grant
Establishment and validation of a stable, cell-based diabetic wound bioassay Principal Investigator: Professor Phil Stephens, Cardiff University Project grant
Carotid artery endothelial growth: a novel in vitro assay Principal Investigator: Dr Atticus Hainsworth, St George's University of London Project grant
Development and validation of mechanisms-based in vitro transformation assays for carcinogen screening Principal Investigator: Professor Robert Newbold, Brunel University Project grant
Inducible SAA transgenic mice: a refined model of human amyloidosis Principal Investigator: Dr Paul Simons, University College London Project grant
Reduction and refinement of murine models of bacterial infection Principal Investigator: Professor Shiranee Sriskandan, Imperial College London Project grant
Development of leucocyte cell lines for immunological research in teleost fish Principal Investigator: Dr Jun Zou, University of Aberdeen Project grant
The development of an in vitro model of central nervous system injury to identify factors which promote repair Principal Investigator: Professor Susan Barnett, University of Glasgow Project grant
Validating a sexual development test using the 3-spined stickleback for addressing the 3Rs in fish toxicity testing Principal Investigator: Dr Ioanna Katsiadaki, Centre for Environment Fisheries and Aquaculture Science Project grant
Development of a mechanistically informative genome-wide, replacement chemicals screening technology Principal Investigator: Professor Andrew Cossins, University of Liverpool Project grant
Refinement of therapeutic intervention in a mouse model of amyotrophic lateral sclerosis Principal Investigator: Dr Andrew Grierson, University of Sheffield Project grant
Pseudoislets as a model system to study beta cell dysfunction in diabetes Principal Investigator: Professor Peter Jones, King's College London Project grant
Modelling the human asthmatic airway by tissue engineering Principal Investigator: Professor Donna Davies, University of Southampton Project grant
Replacement of hamsters with physicochemical analytical methods for Leptospira vaccine batch potency testing Principal Investigator: Dr Nicholas Coldham, Veterinary Laboratories Agency Project grant
A tissue engineering approach to reduce animal use in renal development and renal organ replacement technology Principal Investigator: Professor Jamie Davies, University of Edinburgh Project grant
Reduction, refinement and replacement of animal use by clonal sampling Principal Investigator: Dr Phillip Jones, Hutchison-MRC Research Centre Project grant
Humane endpoints for rodenticide testing Principal Investigator: Dr Alan MacNicoll, Department for Environment Food & Rural Affairs Project grant