Stem cell-derived cardiomyocytes for detection of cardiotoxicity in cancer therapeutics Principal Investigator: Professor Sian Harding, Imperial College London Project grant
A 3D tissue model of breast morphogenesis for replacing animals in testing for endocrine disrupting substances Principal Investigator: Professor Charles Vyvyan Howard, University of Ulster Project grant
Applying the 3Rs to liver fibrosis research Principal Investigator: Professor Matthew Wright, Newcastle University PhD Studentship
The validation of defined genotoxic thresholds, leading to better in vitro risk assessments of carcinogenic potential Principal Investigator: Professor Gareth Jenkins, Swansea University PhD Studentship
Taming anxiety and variation in laboratory mice Principal Investigator: Professor Jane Hurst, University of Liverpool PhD Studentship
Refinement of rearing practices in marmosets Principal Investigator: Professor Hannah Buchanan-Smith, University of Stirling PhD Studentship
An in vitro model system to assay kidney-pathogen interactions determining outcome of Candida albicans infection Principal Investigator: Dr Donna MacCallum, University of Aberdeen PhD Studentship
2Rs (refining and reducing) of animal models of multiple sclerosis Principal Investigator: Professor David Baker, Queen Mary University of London Project grant
Replacement of animals in cancer drug development by using 3D in vitro functional assays for increased predictive power Principal Investigator: Dr Louis Chesler, Institute of Cancer Research Project grant
Assessing the humaneness of gas euthanasia techniques for laboratory rodents Principal Investigator: Dr Huw Golledge, Newcastle University Strategic grant
Transgenic ES Cell Differentiation Systems to replace Transgenic Mouse Analysis of Tissue Specific Regulatory Elements Principal Investigator: Dr Berthold Gottgens, University of Cambridge Project grant
Assessing the welfare of mice used in cancer research Principal Investigator: Dr John Roughan, Newcastle University Project grant
Reducing and replacing mouse use to model the human platelet response in vivo Principal Investigator: Dr Michael Emerson, Imperial College London Project grant
A compartmentalised chamber for the in vitro study and manipulation of axon degeneration Principal Investigator: Professor Victor Perry , University of Southampton Project grant
Drosophila as a model for Alzheimer's disease Principal Investigator: Dr Kevin Moffat, University of Warwick Project grant
Replacing, refining and reducing animal usage in epilepsy research using a non-sentient model Principal Investigator: Professor Robin Williams, Royal Holloway University of London Project grant
Engineering fully functional, integrated skeletal muscle Principal Investigator: Professor Mark Lewis, Loughborough University Project grant
Development and validation of in vitro methods for assaying cancer stem cell responses to therapeutic challenge Principal Investigator: Professor Ian MacKenzie, Queen Mary University of London Project grant
The snail assay as an alternative to the rodent Hershberger assay for detecting androgens and anti-androgens Principal Investigator: Dr Susan Jobling, Brunel University Project grant
Development of induced pluripotent stem (iPS) cells from mutant mouse models in order to reduce animal use Principal Investigator: Dr Majid Hafezparast, University of Sussex Project grant