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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

686 results

Developing an integrated "in vitro carcinogenicity predictive tool" utilising in vitro cell signalling and cell behaviour assessment coupled with in vitro genotoxicity data

Principal Investigator: Professor Gareth Jenkins, Swansea University

Strategic grant

Wireless high-bandwidth trans-cutaneous signal transmission

Principal Investigator: Professor Stuart Baker, Newcastle University

Project grant

Development of human epithelial cell transformation models for carcinogen screening, employing defined phenotypic endpoints mechanistically representative of rate-limiting events in human carcinogenesis

Principal Investigator: Professor Robert Newbold, Brunel University

Strategic grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

The use of gene expression profiles to predict protective immunity without the need for disease challenge

Principal Investigator: Dr Roland Ashford, Veterinary Laboratories Agency

Pilot study grant

An advanced model for neurodegeneration studies in the fruit fly Drosophila melanogaster

Principal Investigator: Dr Ezio Rosato, University of Leicester

Project grant

Replacement of animal models for tumour biology with a multifunctional microfluidic-based approach

Principal Investigator: Professor John Greenman, University of Hull

Project grant

A scientist pipetting liquid into a microtube.

A fully-automated system for positive reinforcement training of group-housed non-human primates

Principal Investigator: Dr Andrew Jackson, Newcastle University

Pilot study grant

The assessment of pain using facial expressions in laboratory mice, rats, rabbits and macaques

Principal Investigator: Dr Matt Leach, Newcastle University

Project grant

Cognition: A miniature wireless EEG system for continuous monitoring of mice brainwave activity

Contractor: Professor Esther Rodriguez-Villegas, Imperial College London

CRACK IT Challenge

Rodent Big Brother: The Trurat Show

Contractor: Professor Douglas Armstrong, Actual Analytics Ltd

CRACK IT Challenge

Rat with white fur and red eyes sitting in the corner of a cage. Sawdust and shredded tissue can be seen on the cage floor.

Cytokines: Improving the predictive capacity of in vitro cytokine release assays to reduce animal use and drug attrition

Contractor: Professor Martin Glennie, University of Southampton

CRACK IT Challenge

IVIVE: Development and mathematical modelling of zonated hollow fibre bioreactors for in vitro to in vivo extrapolation of systemic chemical toxicity

Contractor: Dr Dominic Williams, University of Liverpool

CRACK IT Challenge

BADIPS: The development of cell lines relevant for the discovery of new treatments for bipolar affective disorder

Contractor: Professor Andrew McIntosh, University of Edinburgh

CRACK IT Challenge

Development of a non-lethal sampling method to monitor immune response and disease progression in salmonid fish

Principal Investigator: Dr Bertrand Collet, Marine Scotland Science

Project grant

Pilot study investigating the use human stem cell derived neurons in toxicity testing

Principal Investigator: Dr Eric Hill, Aston University

Pilot study grant

Refining models of fibrotic lung disease

Principal Investigator: Dr Gisli Jenkins, University of Nottingham

Project grant

A collection of test tubes containing coloured liquid

Development of in vitro human and rat proximal tubule cell models as a platform for drug transporter and drug-drug interaction studies

Principal Investigator: Dr Colin Brown, Newcastle University

PhD Studentship

Spontaneous recognition tasks and the 3Rs

Principal Investigator: Dr Alexander Easton, Durham University

PhD Studentship

Dr Alexander Easton with a colleague in conversation

An in vitro model for pain and neurogenic inflammation in the oro-facial region and upper airways

Principal Investigator: Dr Fionnuala Lundy, Queen's University Belfast

PhD Studentship

Neonatal BCG vaccination: screening for genetic factors that influence host-pathogen interactions and reducing and replacing the requirement for animal infection models in immune mechanism discovery

Principal Investigator: Professor Melanie Newport, Brighton and Sussex Medical School

PhD Studentship