Metabolically competent stem cell systems: novel means to implement 3Rs in better drug safety assessment Principal Investigator: Professor Roland Wolf, University of Dundee Project grant
An in vitro model of the human alveolus to predict the efficacy of systemic antifungal therapy Principal Investigator: Professor William Hope, University of Manchester Project grant
Development of a reduced severity rat epilepsy model Principal Investigator: Dr Gavin Woodhall, Aston University Project grant
Non-invasive identification of individual Xenopus by photography and image processing Principal Investigator: Professor Matthew Guille, University of Portsmouth Project grant
In vitro multi-chamber systems for studying neural degeneration processes Principal Investigator: Professor Victor Perry, University of Southampton Project grant
Refinement of a mouse model of pulmonary embolism Principal Investigator: Dr Michael Emerson, Imperial College London Project grant
The use of honeybees to screen for toxins Principal Investigator: Dr Helen Thompson, Food and Environment Research Agency Project grant
An ex vivo mouse mandible culture model to study inflammatory bone disease Principal Investigator: Professor Alastair Sloan, Cardiff University Project grant
Development of alternatives to histamine sensitisation test for pertussis vaccines by in vitro biochemical and biological assays Principal Investigator: Dr Dorothy Xing, National Institute for Biological Standards and Control Project grant
Transcutaneous signal transmission without breaching the skin's natural barrier to infection Principal Investigator: Professor Stuart Baker, Newcastle University Project grant
Development of an in vitro model for the anterior region of the eye Principal Investigator: Dr Nigel Fullwood, Lancaster University Project grant
Development of a new human cell genotoxicity assay to reduce the use of live animals in drug development Principal Investigator: Professor Richard Walmsley, University of Manchester Project grant
Embryonic stem cell-derived cardiomyocytes as a model system for cardiac investigations Principal Investigator: Professor Sian Harding, Imperial College London Project grant
Development of an air-interface in vitro organ culture model (IVOC) of bovine respiratory epithelium Principal Investigator: Dr Alexander Tucker, University of Cambridge Project grant
Development of replacement in vitro assays for the quantification of clostridial vaccine antigens Principal Investigator: Dr Keith Redhead Project grant
The development of a cell-based diabetic wound bioassay Principal Investigator: Professor David Thomas, Cardiff University Project grant
Replacement of the mouse bioassay: Development of SPE and LC-MS for detection of paralytic shellfish poisoning toxins Principal Investigator: Dr Elizabeth Turrell, Marine Scotland Science Project grant
Maintenance of Lutzomyia longipalpis colonies using an artificial membrane blood-feeding method Principal Investigator: Professor Richard Ward, Keele University Project grant
Cell lines for prediction of drug metabolism and toxicity in man Principal Investigator: Professor Charles Wolf, Dundee Technopol CXR Biosciences Ltd Project grant
The reduction in animal usage by multiple antigen immunisation schedules Principal Investigator: Dr Simon Smith, University of Sheffield Project grant