Developing a novel experimental design and analysis model for longitudinal animal studies with high-dimensional outcomes Principal Investigator: Professor Peter Diggle, Lancaster University PhD Studentship
Dissemination of refinements in mouse experimental stroke models to the scientific community Principal Investigator: Dr Claire Gibson, University of Leicester Partnerships and impact awards
Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel Principal Investigator: Dr Luigi Margiotta-Casaluci, Brunel University Strategic grant
Retinal 3D: 3D hiPSC derived laminated retinal model as a tool for toxicology studies Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd CRACK IT Challenge
Osteo-chip: Microfluidic Automated Platform for Osteoarthritis Drug Screening (MA-PODS) Contractor: Professor Anne Dickinson, Alcyomics Ltd CRACK IT Challenge
High-throughput in vitro culture system for Cryptosporidium oocysts: replacing animals in research Principal Investigator: Professor Joanne Cable, Cardiff University Partnerships and impact awards
Non-invasive in vivo tissue imaging with functional optical coherence tomography (OCT) Contractor: Professor Zhihong Huang, University of Dundee CRACK IT Solution
Modelling central and peripheral nervous system connectivity using compartmentalised microfluidic systems Principal Investigator: Dr Federico Dajas-Bailador, University of Nottingham PhD Studentship
Genetic screens in intestinal/colon organoid (mini-gut) culture using the CRISPR-Cas9 system Principal Investigator: Dr Abdolrahman Shams Nateri, University of Nottingham PhD Studentship
Transfer of a non-human primate (NHP) in vitro functional assay for the early evaluation of TB vaccine candidates and the associated immune response Principal Investigator: Dr Rachel Tanner, University of Oxford Partnerships and impact awards
Interrogating the mouse visual system by automated analysis of voluntary behaviour Principal Investigator: Dr Riccardo Storchi, University of Manchester Fellowship
Maximise: Integrated web platform for agro-chemical formulation toxicity classification and data sharing Contractor: Professor Jonathan Timmis, SimOmics Ltd CRACK IT Challenge
The establishment of left-right asymmetry in mammalian development Principal Investigator: Dr David Turner, University of Liverpool Fellowship
Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts Principal Investigator: Dr Anna Grabowska, University of Nottingham PhD Studentship
Neuroinflammation and nociception in a dish Contractor: Professor Adalberto Merighi, University of Turin CRACK IT Solution
Training in hIPSC differentiation protocols to generate motor neuron-muscle cultures to replace rat models in study of mitochondria on axon physiology Principal Investigator: Dr Mark Rigby, King's College London Fellowship
A 3D in vitro glioblastoma cell culture system for identification and evaluation of novel radiosensitisers reducing rodent xenograft studies Principal Investigator: Professor Anthony Chalmers, University of Glasgow Project grant
Development of new experimental models to understand the genetic basis of allergic bronchopulmonary aspergillosis Principal Investigator: Dr Sara Gago, University of Manchester Fellowship
EASE: Design, Fabrication and Testing of a Mouse Embryo Culture Chip Contractor: Dr Virginia Pensabene, University of Leeds CRACK IT Challenge
An industrial standard cancer drug development platform using human induced pluripotent stem cell technology Principal Investigator: Dr Deepali Pal, Newcastle University Fellowship