Refinement of soft tissue targeting and alignment protocols is small animal radiotherapy using an injectable fiducial marker Principal Investigator: Dr Karl Butterworth, Queen's University Belfast PhD Studentship
Moving the Adverse Outcome Pathways Framework towards Practical Utility by Integrating Compound Profiling Data and Using Deep Learning Principal Investigator: Dr Andreas Bender, University of Cambridge PhD Studentship
Multiphoton imaging in human liver tissues: validation of a new tool for drug discovery Principal Investigator: Dr Scott Davies, University of Birmingham Fellowship
Recreating thrombosis models using tissue-engineered arterial constructs: A novel method to reduce and replace mice used in platelet research Principal Investigator: Dr Alan Harper, Keele University PhD Studentship
The Refining Dog Care online learning platform - a modular learning resource for those working with dogs in research Principal Investigator: Dr Laura Scullion Hall, University of Stirling Partnerships and impact awards
Replacing animal models in fungal pathogen research: An in vitro Titan virulence assay for the human fungal pathogen Cryptococcus neoformans Principal Investigator: Dr Elizabeth Ballou, University of Birmingham PhD Studentship
ImmuLiver – An immunologically-competent in vitro model of the human liver for the assessment of Yellow Fever vaccine attenuation Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd CRACK IT Challenge
RaTS - Developing a device for objective monitoring of rheumatoid arthritis progression in rodents Contractor: Associate Professor Martin Hedegaard, University of South Denmark (SDU) CRACK IT Challenge
Development of E-Sense: a flexible in vitro platform to determine cardiovascular risk Principal Investigator: Dr Stephen White, Manchester Metropolitan University PhD Studentship
The role of water chemistry in zebrafish welfare and reproducibility of research studies Principal Investigator: Professor Roderic Wilson, University of Exeter Project grant
Using wireless recording technologies to investigate cortical coherence in a mouse model of dementia Principal Investigator: Dr Jonathan Brown, University of Exeter Partnerships and impact awards
A live model to study mucociliary clearance in health and disease Principal Investigator: Professor David Thornton, University of Manchester Project grant
A highly sensitive replacement assay for botulinum neurotoxin type B Principal Investigator: Dr Andrew Peden, University of Sheffield Project grant
DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects Contractor: Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU) CRACK IT Challenge
A new sensor platform combining plastic antibodies with simple thermal detection Contractor: Dr Marloes Peeters, Manchester Metropolitan University CRACK IT Solution
Development and evaluation of the Animal Welfare Assessment Grid (AWAG) Contractor: Mr Mike Dennis, Public Health England CRACK IT Solution
Novel approach to model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem Cells Principal Investigator: Dr Carola Morell, University of Cambridge Fellowship
Generating in vitro human optic vesicles to dissect the genetic modifiers affecting ocular maldevelopment Principal Investigator: Dr Mariya Moosajee, University College London PhD Studentship
Development of the chick embryo as a replacement for rodent models of tumour metastasis Principal Investigator: Dr Anne Herrmann, University of Liverpool Fellowship
Galleria mellonella - a novel infection model for Mycobacterium tuberculosis aimed at reducing the number of animals in experimentation Principal Investigator: Professor Paul Langford, Imperial College London PhD Studentship