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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

673 results

Standardisation of preclinical PET/CT protocols across multiple research centres

Principal Investigator: Dr Adriana Tavares, University of Edinburgh

PhD Studentship

Automated predictive welfare assessment in groups of fish

Principal Investigator: Professor Oliver Burman, University of Lincoln

Project grant

Towards in vitro oncology trials: drug testing in cultured patient derived tumour organoid cultures

Principal Investigator: Professor Andrew Tutt, King's College London

Project grant

Inter-neuronal variability in human nociceptor electrophysiology: experimentally-driven computational study of response to drugs and channelopathies

Principal Investigator: Dr Oliver Britton, University of Oxford

Project grant

Unravelling the mechanism of transcellular chaperone signalling in C. elegans

Principal Investigator: Dr Patricija van Oosten-Hawle, University of Leeds

Project grant

Using chicken eggs to advance the 3Rs in cancer drug discovery

Contractor: Dr Jean Viallet

CRACK IT Solution

Injecting a chicken egg under a spotlight

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Demuris)

Contractor: Dr Olivia Champion, Biosystems Technology

CRACK IT Solution

Galleria mellonella larvaes in a green tub

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Envigo)

Contractor: Dr Olivia Champion, Biosystems Technology

CRACK IT Solution

Human tissue models for lung disease

Principal Investigator: Professor Maria Belvisi, Imperial College London

Infrastructure grant

Developing a zebrafish model of neurovascular coupling (NVC)

Principal Investigator: Dr Clare Howarth, University of Sheffield

Project grant

Developing alternative models to evaluate the impact of nanomaterials on neutrophils during the stimulation and resolution of inflammation

Principal Investigator: Dr Helinor Johnston, Heriot-Watt University

Project grant

Cas9 mediated in vitro gene editing in primary mammary epithelial cells

Principal Investigator: Dr Walid Khaled, University of Cambridge

PhD Studentship

Reducing animal use in thrombosis research with an ex vivo injury model

Principal Investigator: Dr Matthew Harper, University of Cambridge

PhD Studentship

Developing an Organ on a Chip Model to Test the Therapeutic Efficacy of Adhirons in Breast Cancer

Principal Investigator: Dr Darren Tomlinson, University of Leeds

PhD Studentship

Development of functional 3D human intestinal mucosae to replace rodent models and improve the predictive accuracy of existing in vitro systems

Principal Investigator: Professor Stefan Przyborski, Durham University

PhD Studentship

Developing a Drosophila melanogaster model of the cardiac myocyte action potential to investigate function and performance

Principal Investigator: Dr Jeremy Niven, University of Sussex

PhD Studentship

Reducing animal usage in antifungal drug development: iRFP reporter strains and imaging infection

Principal Investigator: Dr Donna MacCallum, University of Aberdeen

PhD Studentship

Developing Human Glioma OrganDot Cultures

Principal Investigator: Professor William Gray, Cardiff University

PhD Studentship

Refining an in vitro system of predictive biomarkers of in vivo liposome efficacy

Principal Investigator: Dr Andrew Devitt, Aston University

PhD Studentship

Refinement of hematopoietic cell transplantation using optical imaging in zebrafish

Principal Investigator: Professor Margaret Dallman, Imperial College London

PhD Studentship