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NC3Rs | 20 Years: Pioneering Better Science

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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

613 results

Over the last fourteen years, Dr Meri Huch has built a career developing organoids to study human organs in health and disease. This includes developing the first human liver organoids for preclinical research, most notably enabling liver cancer to be studied in vitro.

Headshot of Dr Meritxell Huch

With a decade of NC3Rs funding, scientists at the University of Birmingham have developed the first mature bone organotypic model, then systematically adapted and modified it to replace the use of rodents across a range of therapeutic areas involving the study of bone growth and regeneration.

Dr Alexandra Iordachescu and Dr Liam Grover discuss an organotypic bone model

Professor Anthony Chalmers and Co-Investigator Dr Natividad Gomez-Roman have further developed a 3D human cell culture model replacing the use of mice to evaluate and screen treatments for Glioblastoma (GBM).

A group of researchers stand smiling on a sunny day after having paused on a bike ride.

Dr Alan Harper and NC3Rs-BHF PhD student Jacob Ranjbar have developed an artificial human blood vessel to study blood clotting in vitro and replace the use of mice in thrombosis research. They have successfully disseminated the model to the thrombosis community, including for new applications within cardiovascular research.

Portrait of Dr Alan Harper and Dr Jacob Ranjbar

Dr Paola Campagnolo has used NC3Rs funding from a Project grant and a Skills and Knowledge Transfer award to develop an ex vivo model of the epicardium to replace the use of mice for high throughput screening of cardiac therapies in academia and industry.

Dr Paola Campagnolo on the left with three colleagues on the right side of her in a laboratory