Over the last fourteen years, Dr Meri Huch has built a career developing organoids to study human organs in health and disease. This includes developing the first human liver organoids for preclinical research, most notably enabling liver cancer to be studied in vitro.
The research team of Professors Bazbek Davletov and Andrew Peden, long-term collaborators at the University of Sheffield, have developed in vitro, cell-based assays for replacing animal testing in the manufacture of clostridial toxin-based medical products.
With a decade of NC3Rs funding, scientists at the University of Birmingham have developed the first mature bone organotypic model, then systematically adapted and modified it to replace the use of rodents across a range of therapeutic areas involving the study of bone growth and regeneration.
Professor Anthony Chalmers and Co-Investigator Dr Natividad Gomez-Roman have further developed a 3D human cell culture model replacing the use of mice to evaluate and screen treatments for Glioblastoma (GBM).
Dr Alan Harper and NC3Rs-BHF PhD student Jacob Ranjbar have developed an artificial human blood vessel to study blood clotting in vitro and replace the use of mice in thrombosis research. They have successfully disseminated the model to the thrombosis community, including for new applications within cardiovascular research.
