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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

686 results

Modulating Macrophage Phenotypes During Infection In Zebrafish

Principal Investigator: Dr Phillip Elks, University of Sheffield

PhD Studentship

Developing gene editing technologies in the non-mammalian infectious disease model organism, Galleria mellonella

Principal Investigator: Dr James Pearce, University of Exeter

Fellowship

Refining mouse glucose homeostasis assessments

Principal Investigator: Professor Kate Ellacott, University of Exeter

Partnerships and impact awards

A 3Rs platform for glial research: From animal to human to in-silico models

Principal Investigator: Professor Dmitri Rusakov, University College London

Project grant

High fidelity computational approaches to exploit new structures of cardiac ion channels

Principal Investigator: Dr Andrew Leach, University of Manchester

PhD Studentship

The arm of a researcher pipetting cell culture media into multi-well plates

Drosophila based screening to replace mammalian systems to identify the functional role of candidate genes in controlling muscle dyadic architecture

Principal Investigator: Professor Andrew Trafford, University of Manchester

PhD Studentship

Ensuring humane deaths for laboratory birds

Principal Investigator: Dr Jessica Martin, Newcastle University

PhD Studentship

Development of endometrial/myometrial organoids to study disorders of pregnancy and parturition

Principal Investigator: Dr Andrew Blanks, University of Warwick

Project grant

Replacement in vivo preclinical models to substantially refine and reduce severe protocols used in snakebite envenoming research

Principal Investigator: Dr Stuart Ainsworth, University of Liverpool

Project grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Developing a stem-cell prostate organoid model - reducing global animal usage in prostate development and cancer studies

Principal Investigator: Dr Adriana Buskin, Newcastle University

Fellowship

Modelling of thrombus dynamics in a microfluidic 'vasculature'

Principal Investigator: Dr Nicola Mutch, University of Aberdeen

PhD Studentship

Portrait of Dr Whyte and Professor Mutch

DRIVER Recommendations

Current contact: James Barker

Office-led project

Four bottles of culture medium, in a laboratory setting.

Long-term, self-maintaining primary 3D cultures of mouse and human epithelial tissues for reduction and replacement of animals in research

Principal Investigator: Dr David Fernandez-Antoran, University of Cambridge

Partnerships and impact awards

Grant holder David Fernandez-Antoran sitting at a computer displaying an image of cells.

The application of trabecular bone organoids to investigate mineral-sensing in skeletal physiology and disease

Principal Investigator: Dr Alexandra Iordachescu, University of Birmingham

Partnerships and impact awards

Characterisation of Galleria mellonella innate immune response to Mycobacterium tuberculosis infection

Principal Investigator: Dr Masanori Asai, Imperial College London

Fellowship

Assessing the resource and animal use implications of new EU REACH endocrine disruptor assessment information requirements

Current contact: Dr Natalie Burden

Office-led project

Refinement of pre-exposure programs to reduce the use of fish in proliferative kidney disease monitoring in aquaculture

Principal Investigator: Dr Hanna Hartikainen, University of Nottingham

PhD Studentship

STRATIS: A human-relevant in vitro or ex vivo platform that recapitulates the complex structures of skeletal muscle and the pathology of significant injury to them.

Contractor: Professor Mark Lewis, Loughborough University

CRACK IT Challenge

Accelerating the uptake of non-animal derived antibodies

Current contact: Dr Rachel Eyre

Office-led project

Exploring the role of matrix encapsulation on early developmental decisions using non-animal sourced hydrogels

Principal Investigator: Professor Cathy Merry, University of Nottingham

PhD Studentship