Review of the value of urinalysis assessments in toxicity studies Current contact: Dr Fiona Sewell Office-led project
Review of the use of two species in regulatory toxicology studies: Phase II - molecules following ICH M3(R2) Office-led project
Thyroid Tox: Developing a QSAR and molecular docking tool to predict thyroid receptor-mediated human endocrine disruption Contractor: Dr Paul Thomas, KREATiS CRACK IT Challenge
Virtual Second Species: Applying advanced computational and mathematical modelling approaches to develop a suite of virtual dog tissues and organs to model toxicological endpoints for new chemical entities Contractor: Dr Stephan Schaller, esqLABS GmbH CRACK IT Challenge
A novel approach for modelling the healthy nose-brain axis in vitro Principal Investigator: Professor Róisín Owens, University of Cambridge Project grant
A high-throughput spheroid fusion platform for the templated-assembly of 3D neuromuscular junctions Principal Investigator: Dr Fabrice Gielen, University of Exeter Project grant
A human ex vivo model of haemostasis: A replacement for rodent tail bleeding assays Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University Project grant
A novel in silico framework for early mammalian embryo development Principal Investigator: Professor Tsaneva-Atanasova, University of Exeter Project grant
Human organoid model to generate mucosal immune cell populations Principal Investigator: Dr Joana Neves, King's College London Project grant
Engineering circadian biology into induced pluripotent stem cell organ-on-a-chip models Principal Investigator: Professor David Lee, Queen Mary University of London Project grant
Establishment of a cryo-bank of lineage-committed neural progenitor cells produced from engineered human pluripotent stem cells Principal Investigator: Professor Tilo Kunath, University of Edinburgh Project grant
Organ-on-a-chip model of pulmonary arterial cell-cell interactions Principal Investigator: Dr Beata Wojciak-Stothard, Imperial College London Project grant
Implementing an MEA platform in human neurones for studying age-related neural network dysfunction and testing dietary interventions Principal Investigator: Dr Robert Williams, University of Bath Project grant
Epithelial barrier model: in silico modelling and high throughput assessment Principal Investigator: Dr Malgorzata Wiench, University of Birmingham Project grant
Optimising human stem cell models to decipher signals and responses during organogenesis Principal Investigator: Professor Jennifer Nichols, University of Edinburgh Project grant
Developing a next generation in vitro 3D immune organoids system for studying vaccine-induced immune response and immune-ageing across the life-course Principal Investigator: Dr Qibo Zhang, University of Surrey Project grant
Zebrafish models of Major Depressive Disorder as a replacement for rodent models Principal Investigator: Professor Robert Hindges, King's College London PhD Studentship
Mapping mitochondrial contact sites during neuronal ageing and neurodegeneration in Drosophila Principal Investigator: Dr Alessio Vagnoni, King's College London PhD Studentship
RoboHog: developing an in vitro gut model system of the porcine hindgut Principal Investigator: Dr Anthony Buckley, University of Leeds Project grant
Testing and validation of an in vitro 3D human chondrocyte model to replace animal use in mechanobiology research Principal Investigator: Dr Emma Blain, Cardiff University Project grant