3D patient-derived organoids: A viable and complementary model to study neural system dysfunction in Alzheimer's Disease Principal Investigator: Dr Marc Busche, University College London PhD Studentship
Efficacy of artificial imprinted antibodies in driving unwarranted immune responses Principal Investigator: Dr Shoba Amarnath, Newcastle University PhD Studentship
Human stem cell models of de novo tumorigenesis to replace the use of animals for the study of cancer initiation Principal Investigator: Dr Cinzia Allegrucci, University of Nottingham PhD Studentship
Animal-free in vitro: Adapting established Organisation for Economic Development Test Guideline in vitro assays so that they are free from animal-derived products Contractor: Dr Victoria Hutter, ImmuOne Ltd CRACK IT Challenge
In vitro TDAR: Developing a human in vitro T-cell dependent antibody response (TDAR) assay to assess immune enhancement Contractor: Dr Karla Queiroz, Mimetas B.V. CRACK IT Challenge
Defining drug delivery into and across the oral mucosa using a tissue engineering and mathematical modelling approach Principal Investigator: Professor Craig Murdoch, University of Sheffield Project grant
Reducing and replacing the animal cost of functional genetics in African trypanosomiasis Principal Investigator: Dr Catarina Gadelha, University of Nottingham Project grant
Preclinical Radiomics: A novel approach linking imaging with biological outcomes in mouse models Principal Investigator: Dr Kathryn Brown, Queen's University Belfast Fellowship
Validation of an in vitro humanised 3D haematopoietic system to investigate haematological malignancies Principal Investigator: Professor Helen Wheadon, University of Glasgow Project grant
Refinement of tickling protocols to improve positive animal welfare in laboratory rats Principal Investigator: Professor Alistair Lawrence, Scotland’s Rural College Project grant
Establishing Drosophila melanogaster as part of the pre-clinical pipeline for anti-metastatic cancer drug discovery Principal Investigator: Dr Kyra Campbell, University of Sheffield Project grant
Transfer of an in vitro model for the evaluation of anticoccidial compounds Principal Investigator: Dr Virginia Marugan-Hernandez, Royal Veterinary College Partnerships and impact awards
Replacement of animal use in measuring cardiomyocyte response to drug safety profiling using a novel NMR metabolomics technology Principal Investigator: Dr Rachel Oldershaw, University of Liverpool PhD Studentship
Targeted protein degradation as a novel approach to study protein function in human platelets Principal Investigator: Professor Ingeborg Hers, University of Bristol PhD Studentship
A novel in vitro reporter system for blood stem cell activity Principal Investigator: Professor David Kent, University of York PhD Studentship
Refining the tagging of wild fish and sharks Principal Investigator: Dr Matthew Witt, University of Exeter PhD Studentship
Understanding how altered brain metabolism causes mitochondrial disease Principal Investigator: Dr Joseph Bateman, King's College London PhD Studentship
Combining a fully synthetic hydrogel with human intestinal organoids to model pathological matrix remodelling in Inflammatory Bowel Disease Principal Investigator: Professor Eileen Gentleman, King's College London PhD Studentship
3D bioprinted microtissues to develop patient-specific non-animal technologies (NAT) in cancer drug development Principal Investigator: Dr Deepali Pal, Northumbria University PhD Studentship
Insects as models to study wound healing, infection and the wound microbiome Principal Investigator: Dr Ronan McCarthy, Brunel University PhD Studentship