Developing a human vascularised pancreatic islet on a chip - VIOC Principal Investigator: Dr Victoria Salem, Imperial College London Project grant
Novel in vitro platform to study molecular mechanisms of neurotransmitter release and synaptic plasticity Principal Investigator: Professor Kirill Volynski, University College London Project grant
Testing and validation of an in vitro 3D human chondrocyte model to replace animal use in mechanobiology research Principal Investigator: Dr Emma Blain, Cardiff University Project grant
Improving preclinical proton radiation dosimetry using a biologically relevant murine dosimetry phantom Principal Investigator: Miss Emma Biglin, University of Manchester Fellowship
Embryonic zebrafish models of HACD1-deficiency to replace mammals in congenital myopathy and lipidomic research Principal Investigator: Dr Gemma Walmsley, University of Liverpool PhD Studentship
Investigation of dopamine transporter dysfunction linked to DAT/SLC6A3 mutations in CRISPR-Cas engineered C. elegans and patient derived iPCSs Principal Investigator: Dr Eva Kevei, University of Reading PhD Studentship
Modulating Macrophage Phenotypes During Infection In Zebrafish Principal Investigator: Dr Phillip Elks, University of Sheffield PhD Studentship
Developing gene editing technologies in the non-mammalian infectious disease model organism, Galleria mellonella Principal Investigator: Dr James Pearce, University of Exeter Fellowship
Refining mouse glucose homeostasis assessments Principal Investigator: Professor Kate Ellacott, University of Exeter Partnerships and impact awards
A 3Rs platform for glial research: From animal to human to in-silico models Principal Investigator: Professor Dmitri Rusakov, University College London Project grant
High fidelity computational approaches to exploit new structures of cardiac ion channels Principal Investigator: Dr Andrew Leach, University of Manchester PhD Studentship
Drosophila based screening to replace mammalian systems to identify the functional role of candidate genes in controlling muscle dyadic architecture Principal Investigator: Professor Andrew Trafford, University of Manchester PhD Studentship
Ensuring humane deaths for laboratory birds Principal Investigator: Dr Jessica Martin, Newcastle University PhD Studentship
Development of endometrial/myometrial organoids to study disorders of pregnancy and parturition Principal Investigator: Dr Andrew Blanks, University of Warwick Project grant
Replacement in vivo preclinical models to substantially refine and reduce severe protocols used in snakebite envenoming research Principal Investigator: Dr Stuart Ainsworth, University of Liverpool Project grant
Refining in vivo studies of cancer metastasis with next-generation explant-in-chip perfusion models Principal Investigator: Professor Darryl Overby, Imperial College London Project grant
Developing a stem-cell prostate organoid model - reducing global animal usage in prostate development and cancer studies Principal Investigator: Dr Adriana Buskin, Newcastle University Fellowship
Modelling of thrombus dynamics in a microfluidic 'vasculature' Principal Investigator: Dr Nicola Mutch, University of Aberdeen PhD Studentship
Long-term, self-maintaining primary 3D cultures of mouse and human epithelial tissues for reduction and replacement of animals in research Principal Investigator: Dr David Fernandez-Antoran, University of Cambridge Partnerships and impact awards