Sharp and to the Point: Developing a device for injections in mice that avoids the re-use of needles Contractor: Mr Ian Quirk, Active Needle Technology Ltd CRACK IT Challenge
Validating CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes as tools to assist with toxicity profiling, adverse drug reaction notices and black box warnings Principal Investigator: Professor Chris Denning, University of Nottingham Technologies to tools grant
A computational framework to investigate the mechanical role of the extracellular matrix in tissue development and disease Principal Investigator: Dr Nargess Khalilgharibi, University College London Fellowship
Myocardial slices to study cardiovascular disease in vitro Principal Investigator: Professor Cesare Terracciano, Imperial College London Project grant
A next generation Quiescence and Cell Cycle Indicator for the refinement and reduction of animal usage in proliferation assays Principal Investigator: Dr Richard Mort, Lancaster University PhD Studentship
A novel embryonic zebrafish model to replace mammals in the study of 3-hydroxyacyl CoA dehydratase 1-associated muscle disorders Principal Investigator: Dr Rhiannon Morgan, University of Liverpool Fellowship
Modelling O-GlcNAc transferase intellectual disability syndrome in Drosophila Principal Investigator: Professor Daan van Aalten, University of Dundee PhD Studentship
Engineering Galleria Mellonella as a model for infection, immunity and inflammation Principal Investigator: Dr James Wakefield, University of Exeter Project grant
CleanCut: Developing a human in vitro model to assess the safety of gene edited human haemopoietic stem cells Contractor: Dr Alessandro Rotilio, MOAB srl CRACK IT Challenge
A novel Drosophila platform to replace the use of mice and zebrafish for the study of ER-mitochondria interactions Principal Investigator: Dr Alessio Vagnoni, King's College London Partnerships and impact awards
Developing a chick embryo model to aid in development of personalised therapies for malignant pleural mesothelioma Principal Investigator: Professor Judy Coulson, University of Liverpool Project grant
Do male mice prefer to live on their own? Principal Investigator: Professor Emma Robinson, University of Bristol Project grant
Focused molecular understanding of hypertrophic cardiomyopathy using CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes Principal Investigator: Dr Diogo Mosqueira, University of Nottingham Fellowship
Development of an invertebrate model of alternating hemiplegia of childhood Principal Investigator: Dr Steven Clapcote, University of Leeds PhD Studentship
Fasting-induced torpor in mice: effects on sleep and behaviour Principal Investigator: Professor Vladyslav Vyazovskiy, University of Oxford PhD Studentship
Development and characterization of a novel endothelialized in vitro model of human atherothrombosis Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University PhD Studentship
An organotypic model of the bone remodelling process Principal Investigator: Dr Amy Naylor, University of Birmingham PhD Studentship
A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model Principal Investigator: Dr Adrian Biddle, Queen Mary University of London PhD Studentship
Modelling Candida albicans infection of the human gut using human intestinal organoid cultures Principal Investigator: Dr Silvia Gratz, University of Aberdeen PhD Studentship
Refining weaning age in macaques destined for neuroscience research Principal Investigator: Professor Melissa Bateson, Newcastle University PhD Studentship