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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

673 results

Cerebral organoid models for optical investigation of neural circuit dynamics in neurodegenerative diseases

Principal Investigator: Professor Simon Schultz, Imperial College London

Partnerships and impact awards

Replacing in vivo models with the Quasi vivo system to investigate metastatic site priming by tumour cells

Principal Investigator: Dr Hannah Harrison, University of Manchester

Partnerships and impact awards

Identifying and addressing challenges in fish vitellogenin assessment

Current contact: Dr Natalie Burden

Office-led project

Generation of functionally mature pancreatic organoids as a replacement strategy for animal-models of pancreatitis and pancreatic cancer

Principal Investigator: Dr Jean-Francois Darrigrand, King's College London

Fellowship

Dr Jean-Francois Darrigrand in a white lab coat

Forced swim test in rodents

Current contact: Dr Vicky Robinson

Office-led project

Understanding brain regeneration in a zebrafish larval model of intracerebral haemorrhage

Principal Investigator: Dr Siobhan Crilly, University of Manchester

Fellowship

Investigating biomechanical responses in healthy and diseases ageing cartilage - a tissue engineering approach

Principal Investigator: Dr Katarzyna Pirog, Newcastle University

PhD Studentship

Optimisation and validation of 3D models of progressive human lung fibrosis

Principal Investigator: Dr Joseph Bell, University of Southampton

Fellowship

INDUCE-seq: a novel tool for next generation risk assessment

Principal Investigator: Professor Simon Reed, Cardiff University

PhD Studentship

Using ex vivo organotypic cultures to investigate donor cell integration in the gut

Principal Investigator: Dr Conor McCann, University College London

Project grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

In vitro, off-host, rearing of the poultry red mite to supply parasites for development of new control methods

Principal Investigator: Dr Alasdair Nisbet, Moredun Research Institute

Project grant

MouseMApp: An application to monitor the welfare of mice

Contractor: Dr Matt Leach, Newcastle University

CRACK IT Challenge

MouseMAPP Challenge image of a mouse in a pair of hands

Tat-Fit: Developing a method that allows tamoxifen to be added to rodent chow without changing its palatability or consumption by the animals

Contractor: Dr Fang Liu, Fluid Pharma Ltd

CRACK IT Challenge

Tat fit Challenge image of mouse in cage

A Drosophila single-cell resource for brain metabolism research

Principal Investigator: Dr Alex Gould, The Francis Crick Institute

Project grant

Drug risk assessment and repurposing using biomimetic chromatography and body-on-chip technology

Principal Investigator: Dr Adriana Tavares, University of Edinburgh

PhD Studentship

Establishment of novel macrophage cell lines to study the pathogenesis of respiratory bacterial pathogens in lung alveolar macrophages

Principal Investigator: Dr Gyorgy Fejer, University of Plymouth

Partnerships and impact awards

Direct replacement of secondary antibodies by Affimer proteins

Principal Investigator: Dr Christian Tiede, University of Leeds

PhD Studentship

Re-evaluating the need for mAb chronic toxicity studies

Current contact: Dr Fiona Sewell

Office-led project

Fig. 5. Integrated weight-of-evidence model modified from Chien et al. 2023

Development of a Drosophila-based platform to replace and reduce animal experimentation in epilepsy research

Principal Investigator: Dr Manolis Fanto, King's College London

Project grant

Cryo-storing research lines of chicken to eliminate breeding and save genetic resources

Principal Investigator: Dr Michael McGrew, University of Edinburgh

Project grant