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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

673 results

InPulse: Engineered 2D & 3D hiPSC-CM platforms to detect cardiovascular safety liabilities

Contractor: Professor Chris Denning, University of Nottingham

CRACK IT Challenge

A green graphic of a heart with a pulse signal behind it.

Replacing rodent models for investigating the influence of the microbiome upon innate immune responses and resistance to pathogens

Principal Investigator: Dr Rachel Lawrence, Royal Veterinary College

PhD Studentship

State of the art in vitro models which accurately predict human liver toxicity

Contractor: Dr Dave Hay, University of Edinburgh

CRACK IT Solution

A 3D air-liquid interface airway epithelial cell model to study pathogen interactions within the bovine respiratory tract

Principal Investigator: Dr Robert Davies, University of Glasgow

Project grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

SEARCHbreast: A virtual resource to facilitate sharing breast cancer materials and knowledge to benefit the 3Rs

Principal Investigator: Professor Valerie Speirs, University of Leeds

Infrastructure grant

Non-invasive diffusion tracking in pharmacokinetics

Contractor: Dr Dan Daly, Lein Applied Diagnostics

CRACK IT Solution

A proof-of-concept device that is able to accurately and reproducibly measure the level and distribution of pharmaceuticals within the anterior chambers of excised porcine eyes with high spatial discrimination

EFucci an atlas of proliferation to reduce mouse usage in embryonic proliferation assays

Principal Investigator: Dr Richard Mort, MRC Human Genetics Unit University of Edinburgh

Pilot study grant

Dr Richard Mort with colleagues by a low wall with trees in the background

Towards an in vitro system of predictive biomarkers of in vivo liposome efficacy

Principal Investigator: Dr Andrew Devitt, Aston University

Pilot study grant

Drosophila as a model to understand the role of glial cells in neurodegeneration

Principal Investigator: Dr Manolis Fanto, King's College London

Project grant

Replacement of murine transplantation assays by 3D in vitro substitutes for the assessment of therapeutic responses of cancer stem cells

Principal Investigator: Professor Ian MacKenzie, Queen Mary University of London

Project grant

Professor Ian MacKenzie with a colleague who is using a microscope in a laboratory

An in vitro model to investigate the role of oestrogen and oestrogen metabolism in pulmonary vascular disease

Principal Investigator: Professor Margaret MacLean, University of Glasgow

PhD Studentship

Attention Bias: A novel method to assess psychological well-being in group-housed non-human primates

Principal Investigator: Dr Emily Bethell, Liverpool John Moores University

Pilot study grant

3Rs of murine models of malaria infection: immunology meets experimental genetics

Principal Investigator: Dr Julius Hafalla, London School of Hygiene and Tropical Medicine

Project grant

Reducing animal numbers in tasks of memory

Contractor: Dr Alex Easton, University of Durham

CRACK IT Solution

A white mouse with front feet on a tea cup

Applying the 3Rs to elucidate the mechanisms of tau pathology using DRG neurons in culture

Principal Investigator: Professor Maria Grazia Spillantini, University of Cambridge

Project grant

Novel approaches to immortalise salmon fish cells

Principal Investigator: Dr Bertrand Collet, Marine Scotland Science

Pilot study grant

Multi-user, multi-centre MRI to reduce and refine the use of mice in cancer and trauma research

Principal Investigator: Dr John Marshall, Queen Mary University of London

Infrastructure grant

Establishment of non-transformed, continuously growing, alternatively activated mouse macrophage cell lines

Principal Investigator: Dr Gyorgy Fejer, University of Southampton

Pilot study grant

Development of an in vitro screening system to minimise animal use in the search for factors that modulate (re)myelination

Principal Investigator: Dr Julia Edgar, University of Glasgow

Pilot study grant

Using human pluripotent stem cell-derived cardiomyocytes to test drug cardiac toxicity

Contractor: Dr Tamer Mohammed, University of Manchester

CRACK IT Solution