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3D gene knockout tissue models using adult human stem cells

Principal Investigator: 

  • Professor Paul Genever

Institution: 

  • University of York
  • PhD Studentship

Toxicokinetics in the chemicals industry

  • Office-led project

Impact of rodent age on study outcome

  • Office-led project

Pharmacokinetics in candidate selection

  • Office-led project

Abuse potential studies

  • Office-led project

Reducing the use of recovery animals

  • Office-led project

Reducing animal use in monoclonal antibody development

  • Office-led project

Refining MTD studies

  • Office-led project

The Experimental Design Assistant - EDA

  • Office-led project

NC3Rs/NIH OLAW Experimental design and reporting survey

  • Office-led project

Refining the use of chronic implants in non-human primate neuroscience

  • Office-led project

ARRIVE: Animal Research Reporting In Vivo Experiments

  • Office-led project

In vitro approaches for carcinogenicity testing

  • Office-led project

The snail assay as an alternative to the rodent Hershberger assay for detecting androgens and anti-androgens

Principal Investigator: 

  • Dr Susan Jobling

Institution: 

  • Brunel University
  • Project grant

A chronic model of epilepsy in organotypic brain slice cultures of the rat entorhinal cortex

Principal Investigator: 

  • Professor Roland Jones

Institution: 

  • University of Bath
  • Project grant

Development of cell based assays as replacement assays for Botulinum toxins and antitoxins

Principal Investigator: 

  • Dr Dorothea Sesardic

Institution: 

  • National Institute for Biological Standards and Control
  • Project grant

A tissue engineered construct to monitor mucosal immunity in asthma

Principal Investigator: 

  • Professor Donna Davies

Institution: 

  • University of Southampton
  • Strategic grant

Developing a platform of in vitro models of asthmatic and healthy lung: an alternative to the use of animals in asthma research

Principal Investigator: 

  • Dr Felicity Rose

Institution: 

  • University of Nottingham
  • Strategic grant

The use of gene expression profiles to predict protective immunity without the need for disease challenge

Principal Investigator: 

  • Dr Roland Ashford

Institution: 

  • Veterinary Laboratories Agency
  • Pilot study grant

Refining models of fibrotic lung disease

Principal Investigator: 

  • Dr Gisli Jenkins

Institution: 

  • University of Nottingham
  • Project grant

Development of a non-lethal sampling method to monitor immune response and disease progression in salmonid fish

Principal Investigator: 

  • Dr Bertrand Collet

Institution: 

  • Marine Scotland Science
  • Project grant

Development and validation of an automated test of animal affect and welfare for laboratory rodents

Principal Investigator: 

  • Professor Michael Mendl

Institution: 

  • University of Bristol
  • Project grant

CRANNME: The complete removal of animal use for neuromuscular effectors testing

Principal Investigator: 

  • Professor Mark Lewis

Institution: 

  • Loughborough University
  • Pilot study grant

Live real-time imaging of life-threatening invasive fungal infections

Principal Investigator: 

  • Dr Donna MacCallum

Institution: 

  • University of Aberdeen
  • Pilot study grant

Imprecision and importance: Probabilistic graphical models in toxicology

Principal Investigator: 

  • Dr Jonathan Pitchford

Institution: 

  • University of York
  • Strategic grant

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