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An in vitro model system to assay kidney-pathogen interactions determining outcome of Candida albicans infection

Principal Investigator: 

  • Dr Donna MacCallum

Institution: 

  • University of Aberdeen
  • PhD Studentship

Development of alternatives to histamine sensitisation test for pertussis vaccines by in vitro biochemical and biological assays

Principal Investigator: 

  • Dr Dorothy Xing

Institution: 

  • National Institute for Biological Standards and Control
  • Project grant

Non-invasive identification of individual Xenopus by photography and image processing

Principal Investigator: 

  • Professor Matthew Guille

Institution: 

  • University of Portsmouth
  • Project grant

Reduction, refinement and replacement of animal use by clonal sampling

Principal Investigator: 

  • Dr Phillip Jones

Institution: 

  • Hutchison-MRC Research Centre
  • Project grant

Non-invasive imaging to reduce and refine the use of animals and monitor their welfare during the course of experimentations in oncology

Principal Investigator: 

  • Dr Francois Lassailly

Institution: 

  • Cancer Research UK
  • Pilot study grant

Metabolically competent stem cell systems: novel means to implement 3Rs in better drug safety assessment

Principal Investigator: 

  • Professor Charles R Wolf

Institution: 

  • University of Dundee
  • Project grant

Refinement of therapeutic intervention in a mouse model of amyotrophic lateral sclerosis

Principal Investigator: 

  • Dr Andrew Grierson

Institution: 

  • University of Sheffield
  • Project grant

Replacement of hamsters with physicochemical analytical methods for Leptospira vaccine batch potency testing

Principal Investigator: 

  • Dr Nicholas Coldham

Institution: 

  • Veterinary Laboratories Agency
  • Project grant

Development and validation of mechanisms-based in vitro transformation assays for carcinogen screening

Principal Investigator: 

  • Professor Robert Newbold

Institution: 

  • Brunel University
  • Project grant

Carotid artery endothelial growth: a novel in vitro assay

Principal Investigator: 

  • Dr Atticus H Hainsworth

Institution: 

  • St George's University of London
  • Project grant

Development of leucocyte cell lines for immunological research in teleost fish

Principal Investigator: 

  • Dr Jun Zou

Institution: 

  • University of Aberdeen
  • Project grant

Refinement of animal studies on emesis by defining human biomarkers of nausea

Principal Investigator: 

  • Professor Qasim Aziz

Institution: 

  • Queen Mary University of London
  • Project grant

Inducible SAA transgenic mice: a refined model of human amyloidosis

Principal Investigator: 

  • Dr Paul Simons

Institution: 

  • University College London
  • Project grant

Transgenic ES Cell Differentiation Systems to replace Transgenic Mouse Analysis of Tissue Specific Regulatory Elements

Principal Investigator: 

  • Dr Berthold Gottgens

Institution: 

  • University of Cambridge
  • Project grant

Derivation of conditionally immortalised mouse DRG cell lines

Principal Investigator: 

  • Dr Mohammed Nassar

Institution: 

  • University of Sheffield
  • Project grant

A 3D tissue model of breast morphogenesis for replacing animals in testing for endocrine disrupting substances

Principal Investigator: 

  • Professor Charles Vyvyan Howard

Institution: 

  • University of Ulster
  • Project grant

Development of in vitro assays to determine vaccine efficacy in fish

Principal Investigator: 

  • Professor Christopher Secombes

Institution: 

  • University of Aberdeen
  • Project grant

A fully-automated system for positive reinforcement training of group-housed non-human primates

Principal Investigator: 

  • Dr Andrew Jackson

Institution: 

  • Newcastle University
  • Pilot study grant

Pilot study investigating the use human stem cell derived neurons in toxicity testing

Principal Investigator: 

  • Dr Eric Hill

Institution: 

  • Aston University
  • Pilot study grant

An advanced model for neurodegeneration studies in the fruit fly Drosophila melanogaster

Principal Investigator: 

  • Dr Ezio Rosato

Institution: 

  • University of Leicester
  • Project grant

Replacement of animal models for tumour biology with a multifunctional microfluidic-based approach

Principal Investigator: 

  • Professor John Greenman

Institution: 

  • University of Hull
  • Project grant

Development of a reduced severity rat epilepsy model

Principal Investigator: 

  • Dr Gavin Woodhall

Institution: 

  • Aston University
  • Project grant

Dictyostelium as non-animal model to identify DNA repair pathways as targets for cancer therapy

Principal Investigator: 

  • Dr Nicholas Lakin

Institution: 

  • University of Oxford
  • PhD Studentship

Developing an in vitro approach to study transmission of respiratory viruses

Principal Investigator: 

  • Professor Wendy Barclay

Institution: 

  • Imperial College London
  • Project grant

Validating reward-related behaviour for welfare assessment, and improving welfare through increased predictability of events

Principal Investigator: 

  • Professor Hannah Buchanan-Smith

Institution: 

  • University of Stirling
  • Project grant

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