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3Rs of murine models of malaria infection: immunology meets experimental genetics

Principal Investigator: 

  • Dr Julius Hafalla

Institution: 

  • London School of Hygiene and Tropical Medicine
  • Project grant

In vitro methods for replacement of current in vivo assays for development of drugs against heterogeneous cancer stem cell populations

Principal Investigator: 

  • Dr Adrian Biddle

Institution: 

  • Queen Mary University of London
  • Fellowship

Drosophila as a model to understand the role of glial cells in neurodegeneration

Institution: 

  • King's College London
  • Project grant

The role of bronchoconstriction in the development of airway remodelling and its effects upon lung function

Principal Investigator: 

  • Dr Amanda Tatler

Institution: 

  • University of Nottingham
  • Fellowship

Live imaging of mucosal and vascular inflammation in zebrafish in response to a high cholesterol diet

Principal Investigator: 

  • Professor Margaret Dallman

Institution: 

  • Imperial College London
  • PhD Studentship

Single-cell analysis of replicative fate in vivo by heavy water labelling of DNA and mass spectrometry

Principal Investigator: 

  • Dr Michelle Oyen

Institution: 

  • University of Cambridge
  • PhD Studentship

Refining the study of fatigue in mouse models of chronic liver disease

Principal Investigator: 

  • Dr Claire Richardson

Institution: 

  • Newcastle University
  • Fellowship

The assessment of pain using facial expressions in laboratory mice, rats, rabbits and macaques

Principal Investigator: 

  • Dr Matt Leach

Institution: 

  • Newcastle University
  • Project grant

Assessing the humaneness of gas euthanasia techniques for laboratory rodents

Principal Investigator: 

  • Dr Huw Golledge

Institution: 

  • Newcastle University
  • Strategic grant

Investigation of behavioural and physiological responses to fin-clipping in zebrafish

Principal Investigator: 

  • Ms Gidona Goodman

Institution: 

  • University of Edinburgh
  • Pilot study grant

Combinatorial mathematical modelling & novel toxicological profiling of drug-induced hepatotoxicity

Principal Investigator: 

  • Dr John Ward

Institution: 

  • Loughborough University
  • PhD Studentship

Wireless high-bandwidth trans-cutaneous signal transmission

Principal Investigator: 

  • Professor Stuart Nicolas Baker

Institution: 

  • Newcastle University
  • Project grant

Refinement of the use of fluid control as a motivational tool for non-human primates in neuroscience research

Principal Investigator: 

  • Professor Alex Thiele

Institution: 

  • Newcastle University
  • PhD Studentship

Using the Drosophila fly intestine to investigate Wnt targets in vivo

Principal Investigator: 

  • Dr Owen Sansom

Institution: 

  • University of Glasgow
  • Project grant

FIGCS: An in vitro model to replace ecotoxicity testing of fish to pharmaceuticals

Principal Investigator: 

  • Professor Christer Hogstrand

Institution: 

  • King's College London
  • Project grant

Replacement of animals in cancer drug development by using 3D in vitro functional assays for increased predictive power

Principal Investigator: 

  • Dr Louis Chesler

Institution: 

  • Institute of Cancer Research
  • Project grant

2Rs (refining and reducing) of animal models of multiple sclerosis

Principal Investigator: 

  • Professor David Baker

Institution: 

  • Queen Mary University of London
  • Project grant

Replacing, refining and reducing animal usage in epilepsy research using a non-sentient model

Principal Investigator: 

  • Professor Robin Williams

Institution: 

  • Royal Holloway University of London
  • Project grant

Asthma models

  • Office-led project

Replacing rodent models for investigating the influence of the microbiome upon innate immune responses and resistance to pathogens

Principal Investigator: 

  • Dr Rachel Lawrence

Institution: 

  • Royal Veterinary College
  • PhD Studentship

An in vitro model to investigate the role of oestrogen and oestrogen metabolism in pulmonary vascular disease

Principal Investigator: 

  • Professor Margaret MacLean

Institution: 

  • University of Glasgow
  • PhD Studentship

Multi-user, multi-centre MRI to reduce and refine the use of mice in cancer and trauma research

Principal Investigator: 

  • Dr John Marshall

Institution: 

  • Queen Mary University of London
  • Infrastructure grant

Applying the 3Rs to elucidate the mechanisms of tau pathology using DRG neurons in culture

Principal Investigator: 

  • Professor Maria Grazia Spillantini

Institution: 

  • University of Cambridge
  • Project grant

A 3D air-liquid interface airway epithelial cell model to study pathogen interactions within the bovine respiratory tract

Principal Investigator: 

  • Dr Robert Davies

Institution: 

  • University of Glasgow
  • Project grant

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